Synthesis and In Vitro Pharmacological Evaluation of Indoles and Alkynyl substituted Thieno Pyrimidines, Indazoles and Pyrazoles

Abstract

Investigations embodied in this thesis entitled Synthesis and In vitro newlinePharmacological Evaluation of Indoles and Alkynyl Substituted Thieno pyrimidines, Indazoles and Pyrazoles have been presented in five chapters as follow: newlineChapter 1: Pd/C mediated alkynylation of N-heterocycles This chapter started with the importance of Sonogashira reactions in C C newlinebond-formation and its wide applications in synthetic and organometallic chemistry. This chapter also deals with the importance, use and versatility of Pd/C catalyst and its advantages over other Pd-catalysts. Pd/C is a cheap and air stable catalyst which can be easily recovered from the reaction newlinemixture and is recyclable. The plausible mechanism associated with the Pd/C mediated coupling reactions is also discussed. The later part of this chapter is based on the various reaction approaches utilizing Pd/C catalyst for the synthesis of alkynylated N-heterocycles.