Simultaneous Estimation of Some Antihypertensive Drugs Using Spectroscopic and Chromatographic Methods

Abstract

Background: In Pharmaceutical market, many newer Antihypertensive combinations drugs are available to control hypertension as well as to keep society healthy and stress free. All presently available old drugs have frequent dosing schedule and unpleasant side effects. So there arises need to develop simple, accurate, precise, cost effective, robust, rugged, and perfect analytical methods for new combinations of drugs. So, Development and Validation of various analytical methods for newer Antihypertensive drug combinations becomes a notable contribution to society as well as for Pharmaceutical companies. Henceforth this particular research is of genuine use to Pharmaceutical Society. newlineAim: The objective of present work was, to develop new RP-HPLC, UVSpectroscopic and HPTLC methods for combination drug products. Validation of newly developed analytical methods should be Simple, Accurate, Precise, Selective, Specific, Reproducible, Highly sensitive Solvent stability according to ICH Q2R1 Guidelines. newlineConclusions: All the developed methods were new and followed the ICH guidelines, so methods were found to be suitable for routine quantitative analysis. newline