Stereoselective total synthesis of biologically active lactones: Synargentolide A, Cryptofolione and Cryptocaryalactone along with the development of novel synthetic methodologies

Abstract

The thesis entitled Stereoselective Total Synthesis of Biologically Active Lactones: Synargentolide A, Cryptofolione and newlineCryptocaryalactone along with the Development of Novel Synthetic Methodologies has been divided into three chapters. CHAPTER I: Stereoselective total synthesis of synargentolide A and its epimer newline Natural products containing and#945;, and#946;-unsaturated and#948;-lactone moiety exhibits various pharmacological properties such as cytotoxic, newlineantitumor, antibacterial, ant leukemic and antifungal activities. Synargentolide A 1, a compound of this group was isolated in 1998 by Collett and co-workers from Syncolostemon argentees. The basic structure of and#945;-pyrone 1 is a and#945;,and#946;-unsaturated and#948;-lactone connected to a newlinepolyoxygenated chain. Due to a large range of biological properties this moiety is very attractive to chemists to synthesize. newline