Studies in applications of the baylis-hillman adducts

Abstract

Organic synthesis has been and continues to be one of the most important and successful scientific disciplines having enormous practical utility. The development of synthetic organic chemistry mostly depends on the building block chemistry which essentially involves the formation of new carbon-carbon bonds and various organic transformations. Literature records a number of C-C bond forming reactions such as Grignard reaction, Diels-Alder reaction, Heck reaction, Reformatsky reaction, aldol reaction etc. which have indeed made organic synthesis an useful scientific discipline In recent years, there has been much emphasis on yet another important C-C bond forming reaction i.e. the Baylis-Hillman reaction During the last 10-15 years there has been an exponential growth of this reaction as evidenced by three major reviews and a number of publications and in fact, this reaction is now recognized as one of the important and useful reactions in synthetic organic chemistry. This thesis deals with applications of the Baylis-Hillman chemistry with a view to develop new synthetic methods and consists of three chapters i.e., 1) Introduction, 2) Objectives, Results and Discussion and 3) Experimental. The first chapter, introduction describes briefly the literature reports on recent developments and applications of the Baylis-Hillman reaction. The second chapter deals with the objectives, results, and discussion. The Baylis- Hillman reaction is an emerging C-C bond forming reaction, producing a very useful class of molecules possessing a minimum of three functional groups in close proximity. These Baylis-Hillman adducts have been successfully used in a variety of organic transformations with high stereoselectivities.