Spectrophotometric determinations and single crystal X-ray studies of some drugs and allied compounds

Abstract

In the modern era, drugs play an important role in the progress of human civilization. While primitive man depended mainly on plant product and metal salts to cure diseases, modern man uses a wide range of synthetic organic compounds and biotechnology - derived antibiotics, vaccines, etc. Chemists play an important role in pharmaceutical research, as they synthesize, purify and analyze the drugs. The study of conversion of drugs into medicine and it manufacture, stability and the effectiveness of the drug dosage form is termed as pharmaceutics. There are three important stages in the use of a drug as a medicine, i.e., the discovery of the drug, manufacture of the drug in bulk form and formulation of a drug into different dosage forms like tablet, capsule, injection, syrup etc. In the past few decades, a number of elegant instrumental techniques were reported for the determination of pharmaceutical compounds which are rapid, selective and having a high degree of accuracy. Among these, spectrophotometry is the most important method, which is widely used for variety of materials. Achievement of high accuracy, precision, sensitivity and the ease of availability of spectrophotometer made this technique indispensable for the modern analytical chemists. Analytical chemistry play a vital role in many research areas in chemistry, especially in pharmaceutical industries which rely upon both the qualitative and quantitative chemical analysis and analytical chemist has a major role in modern industrialized society. Techniques frequently employed in pharmaceutical analysis include UV-Vis, AAS and IR. Titrimetric method is an important and still growing area in the field of analytical chemistry due to its versatility, simplicity and rapidity.