Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/18520
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dc.coverage.spatialBiologyen_US
dc.date.accessioned2014-05-21T09:10:05Z-
dc.date.available2014-05-21T09:10:05Z-
dc.date.issued2014-05-21-
dc.identifier.urihttp://hdl.handle.net/10603/18520-
dc.description.abstractPhosphorylation of proteins on tyrosyl residues is an important mechanism for many newlinesignal transduction pathways controlling cell proliferation, differentiation and development. newlineAlthough the phosphotyrosine content of cellular proteins is the net result of the opposing newlineeffects of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), most newlineinvestigators have concentrated on the PTKs, many of which were cloned and sequenced nearly newlinetwo decades ago. Initially, PTPs were thought to be mere household-enzymes that were newlineubiquitously expressed and had low substrate specificity. Following purification and sequencing newlineof the first PTP, PTP1B and subsequent identification of CD45 as a transmembrane PTP, it newlinebecame clear that PTPs are a diverse family of enzymes with many members that have different newlinesubstrate specificities, are regulated differently and are differentially expressed. newlineThe non-transmembrane protein tyrosine phosphatase PTP-S/TC-PTP is ubiquitously newlineexpressed. In rat cells four different forms of this phosphatase are generated from the primary newlinetranscript by alternative splicing. Two of these major forms, PTP-82 and PTP-84 (also known as newlineTC45 and TC48, respectively) are expressed in rat as well as human cells. PTP-82 is located newlinemainly in the cell nucleus, partly in association with chromatin possibly through its interaction newlinewith DNA. The noncatalytic sequences at the carboxy terminal end of PTP-82 and PTP-84 newlinedetermine their subcellular location, substrate specificity, enzyme activity and interaction with newlineDNA and nuclear matrix. PTP-S mRNA is transiently increased upon mitogenic stimulation of a newlinevariety of cells in vitro. During liver regeneration after partial hepatectomy both the major newlineisoforms PTP-82 and PTP-S4 are transiently induced in G1 phase. PTP-82 is specifically newlinephosphorylated on its C-terminal region during mitosis by CK2 or a CK2-Iike enzyme. PTP-S newlinedeficient mice show poor T and B cell proliferative responses and defects in bone marrow newlinehematopoiesis.en_US
dc.format.extentX, 97p.en_US
dc.languageEnglishen_US
dc.relation-en_US
dc.rightsuniversityen_US
dc.titleFunctional characterization of a protein tyrosine phosphatase and its interaction with cellular proteins involved in signal transductionen_US
dc.title.alternative-en_US
dc.creator.researcherGanapati, Umaen_US
dc.subject.keywordCellular and molecular biologyen_US
dc.subject.keywordCellular Proteinsen_US
dc.subject.keywordMolecular Biologyen_US
dc.subject.keywordsignal transductionen_US
dc.description.noteReference P. 77 97en_US
dc.contributor.guideSwarup, Ghanshyamen_US
dc.publisher.placeDelhien_US
dc.publisher.universityJawaharlal Nehru Universityen_US
dc.publisher.institutionCentre for Cellular and Molecular Biologyen_US
dc.date.registeredn.d.en_US
dc.date.completed2001en_US
dc.date.awardedn.d.en_US
dc.format.dimensions-en_US
dc.format.accompanyingmaterialNoneen_US
dc.type.degreePh.D.en_US
dc.source.inflibnetINFLIBNETen_US
Appears in Departments:Centre for Cellular and Molecular Biology

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01_title.pdfAttached File15.4 kBAdobe PDFView/Open
02_certificate.pdf17.07 kBAdobe PDFView/Open
03_acknowledgements.pdf60.9 kBAdobe PDFView/Open
04_contents.pdf135.98 kBAdobe PDFView/Open
05_list of figures.pdf50.91 kBAdobe PDFView/Open
06_list of abbreviations.pdf42.9 kBAdobe PDFView/Open
07_abstract.pdf155.14 kBAdobe PDFView/Open
08_chapter 1.pdf1.29 MBAdobe PDFView/Open
09_chapter 2.pdf960.98 kBAdobe PDFView/Open
10_chapter 3.pdf1.97 MBAdobe PDFView/Open
11_chapter 4.pdf2.19 MBAdobe PDFView/Open
12_chapter 5.pdf2.78 MBAdobe PDFView/Open
13_references.pdf559.45 kBAdobe PDFView/Open


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