STUDIES IN DESIGN AND DEVELOPMENT OF LIPID BASED DRUG DELIVERY SYSTEMS

Abstract

The thesis is about improvement of low/poor oral bioavailability of drug compounds newlinewhich are caused by poor drug solubilisation and/or poor drug absorption. By newlineutilizing well established principles of LDS, this thesis is towards development of newlineformulation alternatives through oral route for an improved clinical efficacy and newlinestability profile. The hypothesis of the current work is that by selection of suitable newlinelipid, surfactant and co-surfactant ratios, desired thermodynamic properties can be newlineachieved which can be indirectly measured using suitable in vitro drug release and in newlinevivo drug absorption studies. Three model drugs, Chlorthalidone, Ramipril and newlineAlitretinoin were selected and included in LDS for developing various dosage forms newlineas tablets, liquid-in-hard gelatin capsule and liquid-in-hard gelatin capsule respectively newlinefor oral administration. The formulation and study design has led to either reduction newlinein dosage amount or improvement in bioavailability and chemical stability profile w.r.t. newlinedrug potency claims and minimizing risk of impurities, resources and complexity newlinereduction in manufacturing operations leading to cost savings. This work will provide newlinerelief from this aspect ensuring significantly reduced exposure to this unintended newlinehealthy population. Ultimately, this will also introduce a superior commercial aspect newlineduring the marketing interactions with registered medical practitioners newline