Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/17828
Title: | Synthesis of novel biologically active organic compounds |
Researcher: | Sreenivasulu M |
Guide(s): | Chandra Sekhar K B |
Keywords: | Organic compounds Chemistry N-heterocyclic carbenes |
Upload Date: | 17-Apr-2014 |
University: | Jawaharlal Nehru Technological University, Anantapuram |
Completed Date: | 24/12/2012 |
Abstract: | The thesis entitled SYNTHESIS OF NOVEL BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS is divided into five chapters. Chapter 1 deals with general survey of literature on and#945;-hydroxy esters, o-acyl mandelic esters and review on importance of N-heterocyclic carbenes in organic chemistry. The chapters 2, 3, and 4 deal with the general survey of literature on the importance of N-heterocyclic carbenes in reduction, hydroacylation and coupling reactions and their use in synthesis of a novel aromatic compounds and experimental procedure for our synthesis of those novel aromatic compounds. Chapter 5 deals with summary and conclusion. Chapter-I: Introduction on N-heterocyclic carbenes In this chapter presents an overview of literature survey on and#945;-hydroxy esters, o-acyl mandelic esters. Also presents review on N-heterocyclic carbenes and its applications in organic chemistry or synthesis of active intermediates. Chapter-II: Synthesis of novel and#945;-hydroxy esters, o-acyl mandelic esters by reduction/hydroacylation of activated ketones with aldedhydes mediated by 1, 3-Bis(2,4,6-trimethylphenyl)imidazolium chloride: In this chapter, we have reported novel and#945;-hydroxy esters and o-acyl mandelic esters by reduction/hydroacylation of and#945;-ketoesters with aldehydes by of 1,3-bis(2,4,6-trimethyl phenyl)imidazolium chloride and triethylamine at ambient temperature via generating N-heterocyclic carbene insitu. An improved catalytic system for hydroacylation/reduction of activated ketones NHC -mediated reduction of and#945;-keto esters in protic solvent Screening of NHC ligands (A-D) with different Bases: xiii The reaction of benzaldehyde 1a with methyl 2-(2-chlorophenyl)-2-oxoacetate 2a in the presence of salts A D (Figure 1) using various bases in methanol (Scheme1). As expected, the carbonyl reduction product 4a was isolated. Among all the salts screened, the use of sterically encumbered 1,3-bis(2,4,6-trimethylphenyl)imidazolium chloride A was found to be the most effective in terms of product yield. |
Pagination: | xxxvii, 237p. |
URI: | http://hdl.handle.net/10603/17828 |
Appears in Departments: | Department of Chemistry |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
01_title.pdf | Attached File | 12.91 kB | Adobe PDF | View/Open |
02_certificate.pdf | 47.37 kB | Adobe PDF | View/Open | |
03_acknowlegements.pdf | 64.6 kB | Adobe PDF | View/Open | |
04_contents.pdf | 150.44 kB | Adobe PDF | View/Open | |
05_preface.pdf | 547.05 kB | Adobe PDF | View/Open | |
06_list of tables and figures.pdf | 168.97 kB | Adobe PDF | View/Open | |
07_chapter 1.pdf | 1.37 MB | Adobe PDF | View/Open | |
08_chapter 2.pdf | 2.18 MB | Adobe PDF | View/Open | |
09_chapter 3.pdf | 1.44 MB | Adobe PDF | View/Open | |
10_chapter 4.pdf | 2.73 MB | Adobe PDF | View/Open | |
11_chapter 5.pdf | 272.66 kB | Adobe PDF | View/Open | |
12-references.pdf | 134.28 kB | Adobe PDF | View/Open | |
13_publication 1.pdf | 1.8 MB | Adobe PDF | View/Open | |
14_publication 2.pdf | 305.69 kB | Adobe PDF | View/Open |
Items in Shodhganga are licensed under Creative Commons Licence Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0).
Altmetric Badge: