quotPHYTOCHEMICAL AND PHARMACOLOGICAL EXPLORATION OF COMMON WEEDS IN DIFFERENT CROPPING SYSTEMS FALLOW LANDS OF THE NILGIRIS AND ITS COMMERCIAL UTILIZATIONquot

Abstract

quotPhytochemical And Pharmacological Exploration of Common Weeds in Different Cropping Systems/Fallow Lands of The Nilgiris and Its Commercial Utilization newline newlineOBJECTIVE - The main objective of this research work is to identify any six prominent weed plants of Nilgiris and to establish the phytochemical and pharmacological importance as a human dual topo-poisons I and II and to make them to utilize commercially newlineMETHODS - After a thorough field survey and literature survey six major weeds of the Nilgiris from 56 identified weeds have been taken for phytochemical and biological studies (Anticancer and wound healing), Molecular docking studies, cell cycle analysis and human topopoison I and II assays. newlineRESULTS - All the weeds proved to have interesting secondary metabolites. First time two flavonoids ( Narangenin and 7 Methoxy Hesperetin ) were isolated from the aerial parts of Erigeron karvinskianus (Asteraceae). A novel saponin glycoside (Tetrahydro-2-(hydroxymethyl)-6-(octadecahydro- 2, 7, 10a-trimethyl-1-propylchrysen-8-yloxy)-2H-Pyran-3, 4, 5-triol was isolated from the aerial parts of Solanum mauritianum (Solanaceae) and a novel ferulic acid derivative 1E-1-hydroxyprop-1-en-2-yl (2E)-3-(4-hydroxy-3-methoxyphenyl) prop-2-enoate) was isolated from the aerial parts of Cytisus scoparius (Fabaceae). All the isolated compounds showed good invitro cytotoxic activity and proved to be safe on Vero cell lines and the compounds also showed good in-vitro wound healing activity. Based on the molecular docking studies, the isolated compounds 2 and 4 showed dual human topo-poison activity at 400 and#956;g/ml dose. All the compounds arresting the cells at S-phase and G2 M phase on HELA cell lines. newlineCONCLUSION - The isolated compounds can be good lead molecules in anticancer drug discovery. The topo-poison I and II studies proved that the compounds II and IV only having dual topo-poisoning activity. The research work proved that these weeds have good medicinal values and can be utilized commercially and be good economical sources to farmers.