Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/16969
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dc.coverage.spatialBiologyen_US
dc.date.accessioned2014-03-06T07:02:49Z-
dc.date.available2014-03-06T07:02:49Z-
dc.date.issued2014-03-06-
dc.identifier.urihttp://hdl.handle.net/10603/16969-
dc.description.abstractThe idea that sugars and saccharide chains may display hydrophobic properties appears counter-intuitive at first sight; however, there are several instances where nonpolar interactions between saccharides and other molecules have been documented. Examination of molecular models of maltose and cellobiose ( a-1 ,4 newlinelinked and ~-1 ,4 linked dimers of D-glucose respectively) reveals that maltose folds newlineinto a L-shaped conformation with the inner face largely containing the methine newlinehydrogens and the outer face dotted with all the hydroxyl groups. Such a fold newlineappeared less likely or favourable in the case of the B-1 ,4 linked cellobiose. In the newlineabsence of any alkyl or aryl substitution, the only hydrophobic character here is newlinederived from the methine CH groups and hence negligibly weak in the monomer itself. newlineBut in the dimer maltose and higher oligomers, as monomers are linked in a newlinerow, an increasing and regular array of these nonpolar faces can develop, thus newlineincreasing the hydrophobic character. Regular repetition and consolidation of the newlinehydrophobic faces into a strip or a ribbon-like surface would be dependent on the newlinetype of the glycosidic linkage. The a-1 ,4 linkage in D-glucose reinforces the newlinehydrophobic surface while ~-1 ,4 linkage breaks this order. Primarily, this is a result newlineof the 4C1 ring conformation that the hexoses adopt, as well as the stereochemical newlineand anomeric constraints that are imposed on the saccharide chain. newlineIn general, four different conformational types are found in polysaccharides, newlinenamely Type A (extended ribbon), Type B (flexible helix), Type C (crumpled newlineribbon) and Type D (flexible coil). Of these the Type B conformation appears most newlinesuited to display amphiphilic properties. A good example is that of the a-(1 ,4)glucoside, newlinedextrin. These are linear analogs of the cyclodextrins, which are cyclic newlineoligoamyloses shaped like a basket whose interior is apolar, while the exterior is newlinehydrophilic and thereby are amphiphilic in nature.en_US
dc.format.extentiv, 110p.en_US
dc.languageEnglishen_US
dc.relation-en_US
dc.rightsuniversityen_US
dc.titleAmphiphilic properties of some sugar chainsen_US
dc.title.alternative-en_US
dc.creator.researcherSundari, C Sivakamaen_US
dc.subject.keywordMolecular Biologyen_US
dc.subject.keywordCellular Biologyen_US
dc.subject.keywordsugar chainsen_US
dc.description.noteReferences p.52-65en_US
dc.contributor.guideBalasubramanium, Den_US
dc.publisher.placeDelhien_US
dc.publisher.universityJawaharlal Nehru Universityen_US
dc.publisher.institutionCentre for Molecular and Cellular Biologyen_US
dc.date.registeredn.d.en_US
dc.date.completed2000en_US
dc.date.awardedn.d.en_US
dc.format.dimensions-en_US
dc.format.accompanyingmaterialNoneen_US
dc.type.degreePh.D.en_US
dc.source.inflibnetINFLIBNETen_US
Appears in Departments:Centre for Molecular and Cellular Biology

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02_dedication.pdf11.21 kBAdobe PDFView/Open
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04_acknolwedgments.pdf71.66 kBAdobe PDFView/Open
05_publications.pdf25.83 kBAdobe PDFView/Open
06_contents.pdf63.93 kBAdobe PDFView/Open
07_abstract.pdf141.99 kBAdobe PDFView/Open
08_chapter 1.pdf687.17 kBAdobe PDFView/Open
09_chapter 2.pdf981.87 kBAdobe PDFView/Open
10_chapter 3.pdf300.59 kBAdobe PDFView/Open
11_chapter 4.pdf608.52 kBAdobe PDFView/Open
12_references.pdf378.13 kBAdobe PDFView/Open


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