Studies towards novel applications of the baylis-hillman chemistry

Abstract

Construction of carbon-carbon bond is one of the most fundamental reactions in organic chemistry and hence the development of new methodologies and strategies for formation of carbon-carbon bonds has been and continues to be one of the most challenging and fascinating endeavors in organic chemistry. Recent developments in organic chemistry demand the concepts of atom economy, selectivity and generation of chemospecific functional groups, for developing any efficient synthetic reaction, particularly C-C bond forming reaction. The Baylis-Hillman carbon-carbon bond forming reaction is one such reaction, well equipped with the concepts of atom economy and generation of densely functionalized molecules. The Baylis-Hillman reaction is basically a three-component reaction involving an activated alkcne, an electrophile and a catalyst (usually a tertiary amine) leading to the coupling of exposition of activated alkene with an electrophile providing an interesting class of highly, synthetically useful multifunctional molecules. This thesis deals with the studies in the applications of Baylis—Hillman chemistry and consists of three chapters, that is, 1. Introduction 2. Objectives, Results & Discussion and 3. Experimental.