Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/15888
Title: Studies on reproductive toxicity of a pyrethroid, cypermethrin in albino mice
Researcher: Nada Mohammed Hamid Al Al-Hamdani
Guide(s): Yajurvedi, H N
Keywords: Zoology
toxicity
pyrethroid
cypermethrin
albino mice
Upload Date: 14-Feb-2014
University: University of Mysore
Completed Date: 2011
Abstract: The objective of the present study was to find out whether or not sub newlinelethal doses of cypermethrin (CYP), i.e.1.38, 2.76 and 5.52 mg/kg body weight newlinecorresponding to 1/476th, 1/238th and 1/119th of LD50 dose of aqueous newlinesuspension administered orally, adversely affect gametogenesis, sex steroid newlinesecretion, fertility, fertility indices, onset of puberty in progeny and accessory newlineorgans of male and female mice and if so whether effects are reversible or not. newlineThe work is divided into two chapters. First one deals with male toxicity and newlinesecond with female toxicity. newlineThree graded doses of CYP as mentioned above, were administered to newlineadult male mice orally through intubation on alternate day for two durations, 6 newlineweeks and12 weeks. There was a dose and duration dependent reduction in i) newlineweight of the body, testes and accessory reproductive organs, ii) serum levels newlineof testosterone, iii) total counts of epididymal spermatozoa whereas there was newlinean increase in abnormal sperm counts compared to controls. Despite these newlineeffects fertility and fertility indices were not affected.The effects of CYP newlinefollowing high dose (5.52 mg/kg body weight) treatment for 12 weeks were not newlinereversible whereas the condition was restored to normalcy in other doses newlinetreated mice within 6 weeks after cessation of treatment. newlineA similar regime of CYP administered i.e. doses and duration, in adult newlinefemale mice caused a dose and duration dependent reduction in, i) weight of newlinethe body, ovary and Fallopian tubes, ii) number of estrous cycles per month, iii) newlineserum levels of estradiol, iv) total number of healthy ovarian follicles whereas newlinethere was an increase in number of atretic follicles of all categories and weight newlineof the uterus compared to controls. There was a significant delay in onset of newlinepuberty and reduction in number of estrous cycles of progeny of medium and newlinehigh dose CYP treated mice mated with normal males.
Pagination: 141p.
URI: http://hdl.handle.net/10603/15888
Appears in Departments:Department of Zoology

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01_title.pdfAttached File85 kBAdobe PDFView/Open
02_declaration.pdf45 kBAdobe PDFView/Open
03_certificate.pdf69.87 kBAdobe PDFView/Open
04_abstract.pdf43.46 kBAdobe PDFView/Open
05_acknowledgements.pdf77.3 kBAdobe PDFView/Open
06_dedication.pdf97.51 kBAdobe PDFView/Open
07_preface.pdf75.91 kBAdobe PDFView/Open
08_contents.pdf42.94 kBAdobe PDFView/Open
09_list of tables.pdf55.89 kBAdobe PDFView/Open
10_list of figures.pdf73.58 kBAdobe PDFView/Open
11_chapter 1.pdf92.62 kBAdobe PDFView/Open
12_chapter 2.pdf8.82 MBAdobe PDFView/Open
13_chapter 3.pdf16.42 MBAdobe PDFView/Open
14_literature cited.pdf995.91 kBAdobe PDFView/Open
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