Synthesis and characterisation of metal complexes of some novel schiff bases

Abstract

The Fe(III), Ru(III), Co(II), Ni(II), Cu(II), Pd(II), Zn(II), Cd(II) and Hg(II) complexes of Schiff bases derived from 4-aminobenzenesulfonamide and 2-hydroxybenzaldehyde (HBABS), furan-2-carbaldehyde (FMABS) and thiophene-2-carbaldehyde(TMABS); pyridine-4-carbohydrazide and thiophene-2-carbaldehyde (TMPCH) and pyrazine-2-carboxamide and thiophene-2-carbaldehyde (TMPCA) have been synthesized and characterized on the basis of elemental analysis, conductance, thermal, magnetic and infrared, electronic and ESR spectral data. Relevant conclusions with respect to the geometry of the complexes have been drawn based on the data obtained. newlineThe work embodied in the thesis also includes results of preliminary investigations of biological activity of the ligands : TMABS, TMPCA and FMABS and their Fe, Ru, Cu, Pd, Zn and Hg complexes against two gram positive bacterial strains: Staphylococcus Aurus; Basillus Subtillus and two gram negative bacterial strains: Salmonella typhi, Escherichia coli and two fungal strains: Aspergillus niger and Penicillium rubrum, wherein the zone of inhibition was measured. The results indicate that the complexes are, in general, more active than the free ligands. Further, Hg complexes, of all the compounds, exert highest activity against the bacteria as well as the fungi studied. newline