In vitro and in silico studies of some wild medicinal plants from North Gujarat forest areas for therapeutic purpose

Abstract

The therapeutic possessions of quite a lot of herbal plants have been renowned in the research in Indian journalism and the arrangements found to helpful in the treatment of diseases. Different antibiotics are available to cure different antibacterial diseases, but bacteria develop resistance against these antibiotics or they show side effects. Plants are among the significant and ordinary sources of potentially important new drugs. The Use of herbal products may provide the best choice to the wide use of synthetic antibiotics. The aspire of this study was to check the level of antibacterial activity of aqueous, organic solvents like petroleum ether, acetone and methanol extracts of Anisomeles indica (L.) O. Ktze., Boswellia serrata Roxb. ex Colebr., Chlorophytum borivilianum Sant. and Fernand, Euphorbia hirta L. and Evolvulus alsinoides L. towards seven bacterial isolates Staphylococcus albus Staphylococcus aureus and Staphylococcus citreus as Gram-positive and Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae as Gram- negative were isolated from hospitalized patients. The assay was done using method of disc diffusion and MIC by Inhibitory Concentrations in Diffusion (ICD) method. Hi-media antibiotics used in the study were Amoxicillin, Bacitracin, Ciprofloxacin, Gentamicin, Nalidixic Acid, Penicillin-G, Streptomycin, Tetracycline were used as standard reference drug. In vitro study, that methanol extract of Anisomeles indica (L.) O. Ktze., Boswellia serrata Roxb. ex Colebr., Chlorophytum borivilianum Sant. and Fernand, Euphorbia hirta L. and Evolvulus alsinoides L. medicinal plants have maximum inhibitory activity and very low MIC accompanied by respectively aqueous, acetone and petroleum ether extracts for both gram positive and negative organisms. The cram shows that plant extracts have wide antimicrobial activity. Therefore, these therapeutic plants the conventional application in the treatment of UTI infectious diseases.