Survey of blood transfusion-induced malaria and other diseases in thalassemia patients from Solapur District (M.S.) India

Abstract

Thalassaemia is the name of a group of genetic, inherited blood disorder passed down through families in which the body makes an abnormal form of hemoglobin. The disorder results in excessive destruction of red blood cells, which leads to anemia. It is not infectious and cannot be passed on from one individual to the other by personal or any other contact, or through blood transfusion, food or air. Thalassaemia is a major health problem, placing an immeasurable emotional, psychological and economic burden on millions of people around the world. Recent data indicate that about 7% of the world s population is a carrier of a hemoglobin disorder and that 300,000-500,000 children are born each year with the severe homozygous states of these diseases. There are two types of thalassemia, namely thalassemia major and thalassemia minor, when defective genes are inherited from either of the parents it is called as minor. When defective genes are inherited from both the parents, it is called thalassemia major. Transfusion is the mainstay of the care of individuals with thalassemia major. The purpose of transfusion is twofold; to improve the anemia and to suppress the ineffective erythropoiesis. Chronic transfusions prevent most of the serious growth, skeletal, and neurological complications of thalassemia major. However, once started, the transfusion-related complications become a major source of morbidity. Standards must be developed and maintained to ensure a safe and rational approach to the use of blood transfusions in the management of these rare disorders. Present work determined the frequency and the prevalence of the thalassemia of the study group, the geographical distribution, clinical findings and hematologic parameters analyses. The data were introduced into electronic system and were statistically analyzed. The current study aims to survey the effect of blood transfusion transmitted Malaria and other diseases in thalassemia patient from Solapur District (M.S.) India.