Study on synthesis of chalcone and pyrimidine heterocyclic compound and their antimicrobial activity

Abstract

The principal of this thesis is One of our aims in research has been the development of new tools and methodologies for drug discovery. The molecular manipulation of promising lead compounds is still a major line of approach to develop new and efficient drugs. In the present study, we undertook the total synthesis of several Chalcones and derivatives of Chalcone. 4-Chloroaniline reacts with 1-(3-hydroxyphenyl)-ethanone in presence of 1-napthonic acid and copper metal as a catalyst (Ullmann reaction) gives 1-(3-(4-aminophenoxy) phenyl) ethanone, which on further condensation with 4-nitrotoluene-2-sulfonylchloride gives N-(4-(3-acetylphenoxy) - phenyl)-2-methyl-5-nitrobenzene -sulphonamide. N-(4-(3-acetylphenoxy)phenyl)-2-methyl-5-nitrobenzenesulphonamide is condensed with different substituted aryl aldehydes at 0 to 5°C using 40% NaOH. The time required for completion of the reaction was 18 to 24 hours. The chalcone produced where yellow, orange and red in color, light weighted and in good yield.