Adiponectin Inflammatory and Oxidative Stress Markers in Obese Healthy Adolescents and Young Adults of Belgaum Urban Population A Cross Sectional Study

Abstract

Introduction: The purpose of the study was to examine differences between healthy obese newlineand non-obese adolescents and young adults, in relation to Adiponectin, inflammatory and newlineoxidative stress markers. newlineObjectives: newlinePrimary Objective: newline To determine the status of hormone Adiponectin in non-obese and obese healthy newlineadolescents and young adults of Belgaum urban population. newlineSecondary Objectives: newline Determination of inflammatory, oxidative stress markers and physical activity newlinestatus by assessing the levels of hs-CRP, C3, C4, Ceruloplasmin, Thiobarbituric newlineAcid Reactive Substance (TBARS), Total Antioxidant Capacity (TAC) and newlinePhysical Activity Score (PAS) in non-obese and obese healthy adolescents and newlineyoung adults. newline To determine the association between Adiponectin, inflammatory, oxidative stress newlinemarkers and physical activity status in healthy obese adolescents and young adults. newlineMethodology: This was a cross-sectional study conducted in 280 participants (140 newlineadolescents and 140 young adults), of these 140, 70 were non-obese and 70 obese. Prescreening newlineof the participants was done for hypertension, diabetes mellitus, and thyroid newlinedisorders, further samples were analysed for hormone adiponectin, hs-CRP, C3, C4, newlineceruloplasmin, cholesterol, TAG, LDL, HDL, TBARS and TAC by standard methods. newlinePhysical activity status was analysed by SQUASH questionnaire. newlineXVIII newlineResults: In healthy obese adolescents adiponectin decreased, while C3,C4, ceruloplasmin, newlineLDL increased, with no much change in the physical activity status. In healthy obese newlineyoung adult s adiponectin, HDL, TAC decreased, with increase in C3, ceruloplasmin and newlinehigher levels of physical activity status. In obese females with ageing adiponectin, HDL, newlineTAC decreased, while C3 and C4 levels increased significantly. Pearson s correlation newlineanalysis showed that with increasing WHR and concentrations of C3, adiponectin newlinedecreased consistently and ceruloplasmin correlated positively with TBARS. newlineHealthy obese adolescents had lower levels of Adiponectin (odds ratio =4.53; pvalue newline= 0.01) and