Physico-chemical studies of biological/biochemical systems

Abstract

In this thesis the work performed on topic physico-chemical study of biological/biochemical systems. It is difficult to explain the term physicochemical study in this abstract, although that an effort has been made to summaries the term in a brief in the light of present work. There are number of researchers continuously going on to perform these studies through out the world which shows self the importance of this work. Thermodynamic properties of aqueous salt solutions of amino acids, small peptides and their derivatives, (which imitate some of the structural features of proteins) assist in understanding the conformational stability and folding behavior of global proteins. In the first part of (part A) present thesis, we have studied the thermodynamic parameters density (and#961;), viscosity (and#951;), ultrasonic velocity (U) and their derived parameters at various temperatures (between 303.15 to 323.15 K), for some basic and#945;-amino acids viz. L-lysine mono-hydrochloride, L-arginine and L-histidine in one molal acetate salt (Sodium acetate, Potassium acetate and Calcium acetate) solutions, while the second part (part B) of the thesis carried out the same study on antibiotic Quinolone drug (levofloxacin) in aqueous and in amino acid (L-glutamic acid and L-aspartic acid) solutions at various temperatures (between 303.15 to 313.15K).Density is a physical property of matter, as each element and compound has a unique density associated with it. Density is defined in a qualitative manner as the measure of the relative quotheavinessquot of objects with a constant volume.