Development and evaluation of parenteral microemulsions of camptothecin for targeting breast cancer

Abstract

Camptothecin CPT is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor solubility in water biocompatible solvents and chemical instability at alkaline pH Hence effective delivery systems are necessitated for the administration of CPT The main objective of the present study was to develop and characterize CPT loaded micro emulsions for the passive active targeted delivery of the CPT to the breast cancer tissues newlineBased on the pseudoternary phase diagrams camptothecin loaded microemulsions CPT MEs camptothecin loaded magnetic microemulsions CPT MMEs and camptothecin loaded polymer stabilized microemulsions CPT PSMEs were prepared Mixtures of benzyl alcohol captex300 3 1 and Capmul MCM were used as oil phase Vitamin E TPGS tween80 1 2 was selected as Smix for CPT MEs CPT MMEs Whereas Solutol HS 15 and newlineSimulsol P 23 12 were selected as Smix for the polymer stabilized microemulsion CPT PSME The selected compositions from the phase diagrams were subjected to thermodynamic stability stress newline