A Chemopreventive approach for the study of Prostate Cancer in chemically induced NMU Testosterone treated Wistar rats

Abstract

Benign prostatic hyperplasia (BPH) and prostate cancer (PCa) are the two major problems associated with prostate in the aged.Prostate specific antigen (PSA) and AR target gene, is thought to contribute to PCa progression. Although metastatic PCa remains an incurable disease at present, therapy can only delay progression. The first step in treatment of metastatic disease is to block testosterone-driven proliferation of PCa cells through androgen deprivation therapy (ADT) or surgical castration. newlineRecent studies have suggested that ADT do not cause complete depletion of androgensPCa requires at least 20-40 years to develop and express its clinical symptoms.because of its long latency, high prevalence, screening complexity and significant mortality and morbidity making it an important target for chemoprevention.Whereas, it is likely that chemoprevention modality of cancer management from pre-neoplastic conditions to high-grade prostatic intraepithelial neoplasia (PIN) is not necessarily eliminate but, it is expected to halt neoplasticity. Suppression of progression of preneoplastic lesions by use of chemopreventive agents certainly would improve morbidity and survival time in PCa patients. newlineThe present work was carried out to minimize the drug induced side effect in prostate associated diseases and to understand the mechanism associated with prostate proliferation, BPH and PCa.The aim was intercepting the disease and prolong the progression phase by use of dietary interventions.Two flavonoids daidzein belonging to isoflavon sub-class and luteolin belonging to flavone sub-class were selected.Both the compounds have been reported to have antioxidant, anti-inflammatory, anti-proliferative properties.Daidzein and luteolin administration maintained the extracellular matrix proteases homeostasis, restored the antioxidant enzyme levels and suppressed inflammation. Only daidzein was able to normalize the lipid profile, where as luteolin did not show any significant change to lipid profile.