Formulation and evaluation of floating drug delivery system of anti ulcer drugs

Abstract

A novel floating drug delivery system of Famotidine and Ranitidine HCl was formulated in an effort to increase the gastric retention time of the dosage form and to control drug release. Among the drugs currently in clinical use are several narrow absorption window, drugs that may benefit from compounding into a floating drug delivery systems. Replacing parenteral administration of drugs to oral pharmacotherapy would substantially improve treatment. It is anticipated that floating drug delivery systems may enhance this possibility. newlineThese accumulated findings of warrant additional research on floating drug delivery system with biocompatible and biodegradable natural polymer, which combine large dimensions with high rigidity to achieve prolonged gastro retentivity. Famotidine and Ranitidine HCl are H2 receptor antagonist drugs. These are widely prescribed in gastric ulcers, duodenal ulcers, Zollinger-Ellison syndrome and gastroesophageal reflux disease. Famotidine has low bioavailability (40 45%) and short biological half-life (2.5-4 hrs) and Ranitidine HCl has short half life (2.2 hrs) and low bioavailability (50%), when oral administration this favours development of a floating drug delivery system to achieve controlled release. Thus, Famotidine and Ranitidine HCl were chosen as suitable drug candidates for floating drug delivery system. However these two drugs have been used to develop many gastro retentive drug delivery systems, but failure in many cases. As we have made an attempt to overcome the problems by utilizing suitable natural polymer and floatation approach. The focus will probably be on floating system as they permit the reduction of synthetic polymers, proper utilization of natural polymers as they have desirable properties such as biocompatible and biodegradation these properties can be obtained from chitosan. It could be possible to modify its characteristics by degree of newlineii newlinedeacetylation to achieve low density, swellability, to become more suitable to deliver the drugs through floating approach.