Investigations on the bioactivity and drug delivery of nanocrystalline hydroxyapatite composites thin films and its surface modification by swift heavy ion irradiation

Abstract

Nowadays, people are affected by different types of diseases or injuries such as tissues damage, bone cancer, dental, hip and knee etc. The effective treatment of these diseases or injuries requires synthetic biomaterials which have the ability to contact and bond with the living tissue, as well as replacement of hard and soft tissues. Surface treatment by irradiation has been identified as a good method to modify the surface properties of implant materials to significantly improve its osseointegration, sterilization and bulk properties. Apart from this, swift heavy ion (SHI) irradiation induces free lattice mismatch of Hap film and improves the bioactivity. Local drug delivery has recently attracted attention to cure the bone infection (osteomyelitis). Recently, drug delivery efficiency of nanosized biomaterials is increased by modification of surface properties and preparation methods. The main aim of the present investigation was to improve the bioactivity of nanosized organic-inorganic composites and HAp thin films, and to investigate its antibiotic drug loading/release behavior. The HAp thin films were prepared by different methods and their surface were modified by swift heavy ion beam irradiation. In addition, the physico-chemical characteristics, biological performance and drug release of the above materials were also investigated. The effect of swift heavy 100 MeV Ag7+ ions irradiation was studied on HAp thin film prepared by PLD technique. The crystallinity of the films was found to decrease with an increase in ion fluence. Decrease in optical band gap for irradiated samples was noted. The surface roughness of irradiated sample increased at lower fluence. Wettability, AMX loading capacity and bactericidal effect increased after irradiation. The irradiated samples showed fast rate of AMX release. The results of the investigations have been published in International journals and presented in several National/International conferences. newline