SYNTHESIS SPECTRAL AND BIOLOGICAL STUDIES OF TRANSITION METAL COMPLEXES OF Cu II Ni II Co II Ru III Pd II AND Pt II OF NOVEL SCHIFF BASE DERIVED FROM 3 CHLORO BENZOHYDRAZIDE KETONES AMINES AND AROMATIC ALDEHYDES

Abstract

There are certain metal ions without which the normal functioning of the living organism is inconceivable. These are Na, K, Mg and Ca. amongst the transition metals are V, Cr, Mn, Fe, Co, Ni, Cu, and Zn. These elements are present in trace and ultra-trace quantities and play vital role at the molecular level in a living system. These transition elements are known to form complexes with the ligands (Schiff s base, semicarbazone and thiosemicarbazone). In fact, these complexes have been known since the mid 19th century1 and even before the general preparation nitrogen-nitrogen-oxygen and nitrogen-nitrogen-sulfur ligands themselves. Metal complexes of Schiff s base, semicarbazone and thiosemicarbazone ligands have occupied a central place in the development of coordination chemistry after the work of Jorgensen and Werner. The properties of transition metal ions which make them particularly suitable for the types of reaction mentioned above are as follows: newline1. They are good lewis acids forming wide range of complexes with nitrogen, oxygen and sulfur donor ligands. newline2. Because of their unfilled d orbital, they have a readily accessible range of oxidation states available for oxidation-reduction reactions. newlineSecond part is perhaps the major difference between the main group and transition metal ions in vivo, but the more covalent nature of the bonding of these ions also produces more directional bonding and quite specific variations in chemical properties, which are a function of the nature of the complexes rather than of the ligand alone. newline newline