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Title: Synthesis of nano hydroxyapatite and its polymer composites for drug delivery and tissue engineering applications
Researcher: Ahymah Joshy M I
Guide(s): Narayanakalkura S
Keywords: Nanohydroxyapatite
Drug delivery
Tissue engineering
Polyacrylamide gel matrix
Upload Date: 16-Jul-2013
University: Anna University
Completed Date: 01/07/2011
Abstract: The regulated formation of crystals in living systems is called biomineralization. It is essential for the proper functioning of hard parts of living beings such as bone, teeth, seashells etc. A biomaterial is any material, natural or synthetic used to replace a part of living systems or to enhance contact with tissues and body fluids. The present investigation aims to synthesis nano rods of pure and lanthanum doped HAp and it s effect on sintering. It further aims to investigate the fabrication of freeze dried degradable polymer HAp/ composite. Further, mineralization of nano HAp in the polyacrylamide gel matrix by varying pH and concentration at physiological pH and temperature (37 ºC). In addition it deals with the influence of inorganic metal ions (Ag, Zn and Fe) on the mineralization of HAp in polyacrylamide gel matrix. Nanorods of pure and lanthanum (0.01-0.05 M) doped HAp was synthesized by sol-gel method. In addition, the effect of sintering on pure and lanthanum doped HAp (0.05 M) samples was also discussed. The in vitro bioactivity test of the samples was performed in simulated body fluid (SBF) and dissolution studies were carried out in phosphate buffer saline (PBS) with pH 7.4. The drug release, haemolysis and antibacterial activity of the samples were also examined. The effect of silver, zinc and iron (0.01, 0.05 and 0.1 M) on the mineralization of HAp in polyacrylamide gel matrix at physiological pH 7.4 and temperature 37 and#1048795;C was also discussed. The samples were characterized using XRD, FTIR and SEM. XRD results confirmed the presence of pure HAp at Fe doped HAp (0.1M). The swelling ratio and in vitro drug release was carried out in PBS. The antibacterial activity of the samples was presented.
Pagination: xxiii, 147p.
Appears in Departments:Faculty of Science and Humanities

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01_title.pdfAttached File38.7 kBAdobe PDFView/Open
02_certificates.pdf1.32 MBAdobe PDFView/Open
03_abstract.pdf24.43 kBAdobe PDFView/Open
04_acknowledgement.pdf14.94 kBAdobe PDFView/Open
05_contents.pdf50.94 kBAdobe PDFView/Open
06_chapter 1.pdf79.08 kBAdobe PDFView/Open
07_chapter 2.pdf7.14 MBAdobe PDFView/Open
08_chapter 3.pdf4.38 MBAdobe PDFView/Open
09_chapter 4.pdf4.47 MBAdobe PDFView/Open
10_chapter 5.pdf5.58 MBAdobe PDFView/Open
11_chapter 6.pdf30.64 kBAdobe PDFView/Open
12_references.pdf50.13 kBAdobe PDFView/Open
13_publications.pdf22.4 kBAdobe PDFView/Open
14_vitae.pdf13.07 kBAdobe PDFView/Open

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