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Title: Protective immune response in plasmodium falciparum malaria: a molecular immunoepidemiological study
Researcher: Sonia Devi Lourembam
Guide(s): Baruah, S
Keywords: Biology
Plasmodium falciparum
Upload Date: 20-May-2013
University: Tezpur University
Completed Date: 2011
Abstract: Malaria is a major health problem with the disease burden mostly borne by economically productive ages. Recent studies indicate the disease is becoming more widespread in south east Asia with 10 of the 11 countries endemic for malaria and with 1.2 billion people at risk of exposure to the disease. India reported the highest malaria confirmed (1563344) and death (1133) cases in 2009 from this region (WHO). The north-eastern region of India (population 28.5 million) is highly endemic for malaria and has been declared as a high risk zone by National Anti Malaria Program. Assam contributes to 64.7% of the malaria positive cases in the north-eastern region of which P. falciparum accounts for 58-75% of the cases and the remainder are due to Plasmodium vivax. Though people living in endemic area develop immunity, which can be either anti disease or anti infection immunity, the factors delineating them are not clear. It is thus felt that an in depth understanding of the immune response leading to anti infection or to anti disease responses in population genetic studies and elucidation of parasite diversity is required for success of malaria control programs. The present study was designed against this perspective with the following objectives: 1) To study the clone multiplicity of the parasite genotypes existing in the study area 2) To elucidate the protective humoral immune response. 3) To elucidate the protective cell mediated immune response. The study was conducted at Guabari village of Baksa district and Kondoli Tea Estate (KTE) of Nagaon district which are mesoendemic for malaria. The two sites differ in population demography and accessibility to health care. Plasmodium falciparum diversity was assessed by typing polymorphic block 2 region of Merozoite Surface Protein 1(MSP-1) gene using primary as well as nested PCR cycles. A high degree of polymorphism in isolates from the two study sites was seen with 33 alleles of MSP-1 seen in Guabari village and 18 alleles at KTE.
Pagination: 167p.
Appears in Departments:Department of Molecular Biology and Biotechnology

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01_title.pdfAttached File16.39 kBAdobe PDFView/Open
02_dedication.pdf9.08 kBAdobe PDFView/Open
03_abstract.pdf72.8 kBAdobe PDFView/Open
04_acknowledgements.pdf16.29 kBAdobe PDFView/Open
05_certificate.pdf18.42 kBAdobe PDFView/Open
06_declaration.pdf11.47 kBAdobe PDFView/Open
07_contnets.pdf70.69 kBAdobe PDFView/Open
08_list of abbreviations.pdf15.42 kBAdobe PDFView/Open
09_list of tables and figures.pdf18.11 kBAdobe PDFView/Open
10_chapter 1.pdf1 MBAdobe PDFView/Open
11_chapter 2.pdf591.84 kBAdobe PDFView/Open
12_chapter 3.pdf635.8 kBAdobe PDFView/Open
13_chapter 4.pdf513.2 kBAdobe PDFView/Open
14_chapter 5.pdf352.82 kBAdobe PDFView/Open
15_chapter 6.pdf819.27 kBAdobe PDFView/Open
16_chapter 6.pdf713.41 kBAdobe PDFView/Open
17_references.pdf243.92 kBAdobe PDFView/Open

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