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Title: Synthesis, characterization and anticancer evaluation of some new Triazole derivatives
Researcher: Dhanya Sunil
Guide(s): Isloor, Arun M
Shetty, Prakasha
Keywords: Chemistry
Antioxidant studies
Anticancer studies
Schiff bases
Mannich bases
Upload Date: 21-Jan-2013
University: Manipal University
Completed Date: 08/08/2012
Abstract: Cancer characterized by uncontrolled, rapid and pathological proliferation of abnormal cells, is the second leading cause of death in humans after cardiovascular diseases in developing as well as advanced countries. Although there are many therapeutic strategies including chemotherapy and radiotherapy, high toxicity and drug resistance limit the positive outcomes in most cases. Moreover most of the chemotherapeutic drugs are expensive. Therefore, novel diagnosis, treatment and prevention approaches are urgently needed for cancer therapy. Research in this direction is still going on, to find an alternative drug which can target the malignant tissues, less toxic and affordable by common man. 1,2,4-triazole derivatives exhibit a wide spectrum of biological activities such as antibacterial, antifungal, antiviral, anticancer etc. The aromatic inhibitors like Anastrazole and Letrozole, which are currently used in the treatment of metastatic breast cancer, are triazole derivatives. Triazole is an important emerging moiety in pharmaceutical study and a lot of work can be carried out on this molecule for obtaining better therapeutic activity. Drugs based on a pyrazole ring have often been occupying a position in the list of best-selling pharmaceutical products since last few decades. Many pyrazole derivatives have been reported to display an array of diverse pharmacological activities such as anti-inflammatory, antimicrobial, antihypertensive, tuberculostatic, analgesic, antidiabetic, antileishmanial and antitumor. Prompted by the therapeutic importance of 1,2,4-triazoles and pyrazoles, it was intended to synthesize five series of triazole derivatives: Schiff bases, Mannich bases, Thiadiazoles, Thiazolidinones and Thiadiazepines which incorporated the bioactive pyrazole moiety. The structures of the newly synthesized molecules were confirmed by IR, 1H-NMR, mass spectra and C,H,N analyses. The in vitro antioxidant and anticancer studies of the triazole derivatives were carried out.
Pagination: 206p.
Appears in Departments:Department of Chemistry

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01_title.pdfAttached File18.54 kBAdobe PDFView/Open
02_certificate.pdf172.95 kBAdobe PDFView/Open
03_abstract.pdf102.48 kBAdobe PDFView/Open
04_declaration.pdf161.78 kBAdobe PDFView/Open
05_acknowledgement.pdf173.11 kBAdobe PDFView/Open
06_contents.pdf38.25 kBAdobe PDFView/Open
07_list of tables.pdf100.27 kBAdobe PDFView/Open
08_list of figures.pdf195.21 kBAdobe PDFView/Open
09_list of schemes.pdf181.17 kBAdobe PDFView/Open
10_chapter1.pdf1.18 MBAdobe PDFView/Open
11_chapter2.pdf494.67 kBAdobe PDFView/Open
12_chapter3.pdf1.35 MBAdobe PDFView/Open
13_chapter4.pdf1.31 MBAdobe PDFView/Open
14_chapter5.pdf985.11 kBAdobe PDFView/Open
15_chapter6.pdf1.15 MBAdobe PDFView/Open
16_chapter7.pdf1.46 MBAdobe PDFView/Open
17_conclusion.pdf119.37 kBAdobe PDFView/Open

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