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Title: Genetic study on refractory anemia group of myelodysplastic syndromes MDS RA
Researcher: Venkateswaran N
Guide(s): Venkatachalam P
Keywords: Myelodysplastic syndromes
Biomedical Sciences
Upload Date: 6-Sep-2012
University: Sri Ramachandra Medical College and Research Institute
Completed Date: July, 2010
Abstract: Myelodysplastic syndromes (MDS) are clonal disorders characterized by ineffective hematopoiesis and peripheral cytopenias [1] and reported as hematological malignancy of all age groups including childhood. Generally, morphological examination of marrow smear remains the cornerstone of diagnosis of MDS. In ambiguous cases, a cytogenetic evaluation is suggested to correlate morphological findings and confirm diagnosis. While, the diagnosis of MDS is also complemented by cytogenetics [2], there are no cytogenetic abnormalities specific or consistent for any morphologic subgroup of MDS. Chromosomal abnormalities would ultimately lead to the discovery of the genetic lesions important in the pathogenesis of MDS. Existing therapeutic options for MDS patients include supportive care, low/highintensity therapy. However, therapeutic dilemmas exist because of disease heterogeneity and patient age. Hence, development of an effective therapeutic protocol inevitably requires additional investigations in understanding the initial genetic event of the presumed multi-step pathogenesis of MDS. Molecular studies suggest that pathogenetic lesions in MDS relate to ineffective hematopoiesis and enhanced apoptosis of hemopoietic cells within MDS marrow. Hence, signaling molecules and the pathways involved in mediating apoptosis was extensively analyzed and a hypothesis was developed that in addition to pro-inflammatory cytokines such as tumor necrosis factoralpha newline(TNF- and#61537;), tumor necrosis factor-beta (TNF- and#61538;) and interferon-gamma (INF- and#61543;), transcription factors like NF-and#954;B also involve/influence the pathogenesis of MDS [3]. It has been demonstrated that polymorphisms in genes of cytokines might have direct functional significance by altering level of genes expression and/or its function in many types of cancer [4].
Pagination: xii, 150p.
Appears in Departments:College of Biomedical Sciences

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02_certificates & declaration.pdf112.71 kBAdobe PDFView/Open
03_acknowledgements.pdf112.06 kBAdobe PDFView/Open
04_abbreviations.pdf158.86 kBAdobe PDFView/Open
05_abstract.pdf188.23 kBAdobe PDFView/Open
06_contents.pdf110.66 kBAdobe PDFView/Open
07_chapter 1.pdf1.93 MBAdobe PDFView/Open
08_chapter 2.pdf703.5 kBAdobe PDFView/Open
09_chapter 3.pdf165.61 kBAdobe PDFView/Open
10_chapter 4.pdf312.03 kBAdobe PDFView/Open
11_chapter 5.pdf483.1 kBAdobe PDFView/Open

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