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Title: Investigation of alteration in insulin signaling due to prolonged hyperinsulinemia on 3T3 L1 adipocytes
Researcher: Jyothi kumara P
Guide(s): Lakshmi B S
Keywords: Chronic hyperinsulinemia
Type 2 diabetes mellitus
Upload Date: 10-Feb-2015
University: Anna University
Completed Date: 01/10/2014
Abstract: Type 2 diabetes mellitus T2DM is reaching epidemic proportions newlineworldwide with an increasing percentage of the adult population being affected newlineThe pathogenesis of T2DM results due to insulin resistance in target tissues with newlinean impairment in insulin secretion Among the various factors hyperinsulinemia newlineplays a crucial role in the development of insulin resistance Hyperinsulinemia newlinecondition develops into the two pathophysiological disorders T2DM and obesity newlineAlthough there are various pharmacological approaches for the management of newlineinsulin resistance they have been reported to exhibit several side effects As an newlinealternative to the existing allopathic treatments natural therapeutic approaches are newlinebeing investigated due to their limited side effects The present study investigates newlinethe role of hyperinsulinemia in impaired insulin signaling and explores an herbal newlinebased therapeutic approach for reverting hyperinsulinemia induced insulin newlineresistance in 3T3 L1 adipocytes newlineChronic hyperinsulinemia treatment in in vitro was studied by newlineincubating differentiated 3T3 L1 adipocytes with logarithmic 0 01 0 1 and 1 and#956;M newlinedoses of insulin referred to as hyperinsulinemia for different time periods 4 8 newlineand 12 h Hyperinsulinemia was found to impair insulin stimulated glucose newlineuptake in a dose and time dependent manner in 3T3 L1 adipocytes with a complete newlineinhibition observed at 12 h newline
Pagination: xxv, 147p.
Appears in Departments:Faculty of Science and Humanities

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01_title.pdfAttached File82.12 kBAdobe PDFView/Open
02_certificate.pdf1.32 MBAdobe PDFView/Open
03_abstract.pdf67.23 kBAdobe PDFView/Open
04_acknowledgement.pdf9 kBAdobe PDFView/Open
05_content.pdf59.01 kBAdobe PDFView/Open
06_chapter1.pdf1.06 MBAdobe PDFView/Open
07_chapter2.pdf162.43 kBAdobe PDFView/Open
08_chapter3.pdf2.12 MBAdobe PDFView/Open
09_chapter4.pdf56.88 kBAdobe PDFView/Open
10_reference.pdf1 MBAdobe PDFView/Open
11_publication.pdf24.32 kBAdobe PDFView/Open

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