Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/336449
Title: Induction of Memory T Cells by Mimicking Natural Course of Infection
Researcher: Bhurani, Vishakha
Guide(s): Dalai, Sarat
Keywords: Immunology
Life Sciences
mimicking
TLR Ligands
University: Nirma University
Completed Date: 2020
Abstract: Inducing robust and sustained T cell responses is necessary for therapeutic intervention of most infectious diseases. Unfortunately, many current subunit vaccine regimens fail to induce substantial cellular immunity. Potent cellular responses are an absolute necessity when it comes to achieving a state of complete protection and durable immunological memory in host systems. Vaccine invention and development has its roots lying under the concept of natural infection induced memory. Thus, mimicking infection can represent a good road map for guiding the development of novel subunit vaccine regimens. It has been noted that often responses to vaccination differ from those induced by infectious challenge, naturally. The failure of vaccines to a greater extent could be correlated to an incomplete understanding of the signals and cell types that operate at different stages of the immune response to influence the quantity and quality of developing memory T cells. Immunological rules guiding subunit vaccine elicited T cell responses would not be very different from those guiding infection induced T cell responses. Hence, understanding infection in its natural settings could help in designing better antigen-adjuvant systems and strategies, for generating multifunctional memory responses. newlineIn our study we wished to obtain insights on the effects of fragmenting doses of antigen and adjuvant on memory T cell generation in a typical natural viral infection setting. We thus designed two objectives each focusing on initial/acute phase and contraction/resolution phase of infection. As part of first objective, we intended to mimic infection by administering TLR ligands as adjuvants and OVA as model antigen; following the course of infection. We immunized groups of C57BL/6 mice with combinations of TLR agonists (R848 + Poly I: C to mimic viral infection) along with Ag OVA by creating conditions analogous to graded inflammation and Ag dose. By adopting the modified approach, we found enhanced memory CD4+ T cell response
Pagination: 
URI: http://hdl.handle.net/10603/336449
Appears in Departments:Institute of Science

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02_certificate.pdf429.67 kBAdobe PDFView/Open
03_abstract.pdf289.5 kBAdobe PDFView/Open
04_declaration.pdf378.38 kBAdobe PDFView/Open
05_acknowledgement.pdf184.24 kBAdobe PDFView/Open
06_contents.pdf281.02 kBAdobe PDFView/Open
07_list of tables.pdf179.7 kBAdobe PDFView/Open
08_list of figures.pdf291.98 kBAdobe PDFView/Open
09_abbreviations.pdf283.23 kBAdobe PDFView/Open
10_chapter 1.pdf306.81 kBAdobe PDFView/Open
11_chapter 2.pdf856.12 kBAdobe PDFView/Open
12_chapter 3.pdf966.86 kBAdobe PDFView/Open
13_chapter 4.pdf3.61 MBAdobe PDFView/Open
14_conclusion.pdf190.47 kBAdobe PDFView/Open
15_summary.pdf310.12 kBAdobe PDFView/Open
16_bibliography.pdf194.63 kBAdobe PDFView/Open
80_recommendation.pdf618.25 kBAdobe PDFView/Open
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