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Title: In silico investigations on the Regulatory mechanism of Endothelial nitric oxide synthase
Researcher: Devika N T
Guide(s): Jaffar ali B M
Keywords: Endothelial nitric oxide
Kinetikit platform of GENESIS
Nitric Oxide
Nitric oxide synthasee
Upload Date: 3-Feb-2015
University: Anna University
Completed Date: 01/08/2014
Abstract: The vascular endothelium the inner lining of vessel wall expresses newlineendothelial nitric oxide synthase eNOS an enzyme that generates the newlinevasoprotective molecule Nitric Oxide NO that regulates vascular newlinehomeostasis angiogenesis and vascular remodelling processes Multiple and newlineinterdependent control mechanisms regulates its activity for optimal newlineproduction of NO Employing computational approaches this thesis newlineinvestigates the regulatory mechanism of this important enzyme bringing in newlinedetail the mechanochemical signal transduction pathway structural cues in newlinephosphorylation dephosphorylation events and the protein interaction newlineunderlying the signalling events newlineA systems biology approach at cellular level has been put forth to newlinemodel the eNOS activation process regulated by multiple molecular signal newlinetransduction pathways The signalling pathways were quantitatively solved as newlinemass action or enzymatic reactions represented by first order second order newlinedifferential equations developed using the Kinetikit platform of GENESIS an newlineopen source reaction kinetic simulator newline newline
Pagination: xxii, 152p.
Appears in Departments:Faculty of Science and Humanities

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01_title.pdfAttached File27.6 kBAdobe PDFView/Open
02_certificate.pdf508.2 kBAdobe PDFView/Open
03_abstract.pdf13.83 kBAdobe PDFView/Open
04_acknowledgement.pdf7.05 kBAdobe PDFView/Open
05_content.pdf64.18 kBAdobe PDFView/Open
06_chapter1.pdf347.01 kBAdobe PDFView/Open
07_chapter2.pdf101.26 kBAdobe PDFView/Open
08_chapter3.pdf930.37 kBAdobe PDFView/Open
09_chapter4.pdf2.01 MBAdobe PDFView/Open
10_chapter5.pdf2.26 MBAdobe PDFView/Open
11_chapter6.pdf269.78 kBAdobe PDFView/Open
12_appendix.pdf317.23 kBAdobe PDFView/Open
13_reference.pdf99.18 kBAdobe PDFView/Open
14_publication.pdf7.13 kBAdobe PDFView/Open

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