Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/3268
Title: Development of new synthetic route for Asymmetric synthesis of (R)-Mexiletine, (R)-Phenoxybenzamine, (S)-Dapoxetine, (R)-Selegiline and (R)-Rasagiline using hydrolytic kinetic resolution and asymmetric epoxidation-reduction strategies
Researcher: Sasikumar, M
Guide(s): Nikalje, Milind D
Keywords: Chemistry
Synthesis
Upload Date: 9-Nov-2011
University: University of Pune
Completed Date: December, 2010
Abstract: The Chapter 1: describes the asymmetric synthesis of antiarrhythmic drug (R)-Mexiletine and anti-hypertensive drug (R)-Phenoxybenzamine using hydrolytic kinetic resolution (HKR). Chapter 2: represents the asymmetric synthesis of selective serotonin reuptake inhibitor (S)-Dapoxetine and Monoamine Oxidase (MAO-B) Inhibitor (R)-Selegiline using Sharpless asymmetric epoxidation strategy. Chapter 3: deals with asymmetric synthesis of calcium receptor agonist (calcimimetic) (+)-NPS R- 568 and Monoamine Oxidase (MAO-B) Inhibitor (R)-Rasagiline via chiral spiroborate catalyzed asymmetric reduction.
Pagination: 271p.
URI: http://hdl.handle.net/10603/3268
Appears in Departments:Department of Chemistry

Files in This Item:
File Description SizeFormat 
01_title.pdfAttached File175.53 kBAdobe PDFView/Open
02_certificate.pdf130.93 kBAdobe PDFView/Open
03_declarations.pdf122.37 kBAdobe PDFView/Open
04_contents.pdf171.79 kBAdobe PDFView/Open
05_acknowledgements.pdf86.77 kBAdobe PDFView/Open
06_abbreviations.pdf122.9 kBAdobe PDFView/Open
07_general remarks.pdf87.23 kBAdobe PDFView/Open
08_abstract.pdf180.19 kBAdobe PDFView/Open
09_chapter 1.pdf760.45 kBAdobe PDFView/Open
10_chapter 2.pdf760.41 kBAdobe PDFView/Open
11_chapter 3.pdf738.89 kBAdobe PDFView/Open


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