Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/31182
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dc.coverage.spatialHuman Geneticsen_US
dc.date.accessioned2014-12-19T09:47:02Z-
dc.date.available2014-12-19T09:47:02Z-
dc.date.issued2014-12-19-
dc.identifier.urihttp://hdl.handle.net/10603/31182-
dc.description.abstractIntroduction: Dose evaluation of exposed humans to radiation becomes necessary newlineafter exposure. Such a dose evaluation can be done by biological dosimetric methods newlineof which increased somatic cell mutant frequencies in exposed individuals can be a newlinereliable index [1]. Biological dosimetry has an important role to play in assessing the newlinecumulative radiation exposure of persons working with radiation and also in newlineestimating the true dose received during accidents involving external and internal newlineexposure. Biodosimetric methods include cytogenetic, immunological and mutational assays [2]. The need for biodosimetry is essential for caliberating the actual dose received to a biological system where other conventional forms of dosimetry are unavailable. Even in the presence of other dosimetric tools such as Thermo Luminescent Devices (TLDs) etc, biological dosimetry gives actual doses apart from an indication of the extent of damage caused by such damages. This becomes all the more important newlinewith the current situations such as space programmes and dirty bombs. There are currently many advancing methods for measuring somatic mutations and new opportunities for biological dosimetry of high-risk groups. An evaluation of such mutations becomes all the more important, as such mutations can be possible predictors of cancer risk [3]. Somatic mutations can now be measured in several human genes. The genes currently used include the hemoglobin (Hb) genes on chromosome 11 and 16, the glycophorin A (GPA) gene on chromosome 4, the newlinehypoxanthine-guanine phosphoribosyltransferase (HPRT) gene on the Xchromosome, the HLA genes on the chromosome 6 and the T-cell receptor (TCR) genes on chromosomes 7 and 14. Of the various assays for somatic mutations, only GPA and HPRT have been studied sufficiently to have reliable databases. newlineen_US
dc.format.extent131p.en_US
dc.languageEnglishen_US
dc.relation--en_US
dc.rightsuniversityen_US
dc.titleAnalysis of somatic cell mutations at the Glycophorin a locus in human erythrocytesen_US
dc.title.alternativeen_US
dc.creator.researcherMaddaly Ravien_US
dc.subject.keywordGlycophorinen_US
dc.subject.keywordHuman erythrocytesen_US
dc.subject.keywordHuman Geneticsen_US
dc.description.noteReference included in chapters, List of publications includeden_US
dc.contributor.guidePaul, Solomon F Den_US
dc.publisher.placeChennaien_US
dc.publisher.universitySri Ramachandra Universityen_US
dc.publisher.institutionDepartment of Human Geneticsen_US
dc.date.registeredJuly, 2001en_US
dc.date.completedJanuary, 2005en_US
dc.date.awarded2005en_US
dc.format.dimensions--en_US
dc.format.accompanyingmaterialNoneen_US
dc.source.universityUniversityen_US
dc.type.degreePh.D.en_US
Appears in Departments:Department of Human Genetics

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01_title.pdfAttached File87.19 kBAdobe PDFView/Open
02_certificate & declaration.pdf359.99 kBAdobe PDFView/Open
03_acknoledgements.pdf9.58 kBAdobe PDFView/Open
04_contents.pdf310.72 kBAdobe PDFView/Open
05_abstract.pdf125.67 kBAdobe PDFView/Open
06_chapter_1.pdf1.64 MBAdobe PDFView/Open
07_chapter_2.pdf167.02 kBAdobe PDFView/Open
08_chapter_3.pdf147.34 kBAdobe PDFView/Open
09_chapter_4.pdf266.54 kBAdobe PDFView/Open
10_chapter_5.pdf992.65 kBAdobe PDFView/Open
11_chapter_6.pdf268.27 kBAdobe PDFView/Open
12_chapter_7.pdf366.22 kBAdobe PDFView/Open
13_chapter_8.pdf73.46 kBAdobe PDFView/Open
14_chapter_9.pdf288.19 kBAdobe PDFView/Open
15_conclusion.pdf92.43 kBAdobe PDFView/Open
16_references.pdf383.94 kBAdobe PDFView/Open
17_publications.pdf62.84 kBAdobe PDFView/Open


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