Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/298657
Title: Bioactivity phytochemical screening and synthesis of potent nanoparticle from some mangrove and weed species of south West Bengal against uropathogens
Researcher: Saha, Sunayana
Guide(s): Sikdar (née Bhakta), Mausumi
Keywords: Life Sciences
Microbiology
University: Presidency University
Completed Date: 2020
Abstract: Plants are generating an ever increasing interest due to their effectiveness, low cost and minimum side effects associated with drugs derived from them.Nowadays infection from common pathogens are mostly resistant to several antibiotics which undermine their ability to control the infections. Sufferings from Urinary Tract Infection (UTI) across the globe is alarming. Four mangrove species found in Sundarban areas of West Bengal, namely-Avicennia alba Blume.,Avicennia marina(Forssk.) Vierh., Brugeiracylindrica(Linnaeus) Blume and SonneratiaapetalaBuch.-Ham and two weed species found in Southern part of West Bengal, namely,- LippianodifloraL., Chlerodendruminfortunatum(Linn)are selected to investigate their antibacterial activity against two epidemiologically most prevalent uropathogens of Eastern India Escherichia coli and Klebsiellapneumoniae.Antioxidant content and LC-MS analysis of the plant leaves were studied. As they synthesize a large amount of bioactive compoundsthe selected plant leaves are employed to reduce silver nitrate to silver nanoparticles. Their efficacy as antimicrobials and their characterization were investigated in this study. The characterization of the AgNPwere done by UV-vis spectrophotometer, Fourier Transformed Infra Red Spectroscopy, Zeta Potential and X-ray Diffraction, Transmission Electron Microscope and Scanning Electron microscope. The study of synergistic effect of AgNP with different antibiotics depicted enhanced antibacterial activity of the antibiotics. The cytotoxic level of the synthesized nanoparticles against human red blood cells and human kidney cells were also reported. This study forms the foundation for development of alternate drugs to treat resistant human pathogens. Further investigations of the plant extracts to identify the bioactive compounds will be beneficial in alternate drug formulations as well as drug modifications. newline
Pagination: x, 129p.
URI: http://hdl.handle.net/10603/298657
Appears in Departments:Department of Life Sciences

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02_certificate.pdf761.46 kBAdobe PDFView/Open
03_preliminary pages.pdf1.34 MBAdobe PDFView/Open
04_chapter 1.pdf263.55 kBAdobe PDFView/Open
05_chapter 2.pdf485.38 kBAdobe PDFView/Open
06_chapter 3.pdf757.48 kBAdobe PDFView/Open
07_chapter 4.pdf2.84 MBAdobe PDFView/Open
08_chapter 5.pdf263.02 kBAdobe PDFView/Open
09 _chapter 6.pdf246.51 kBAdobe PDFView/Open
10_references.pdf404.7 kBAdobe PDFView/Open
11_annexures.pdf4.33 MBAdobe PDFView/Open
80_recommendation.pdf250.19 kBAdobe PDFView/Open


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