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Title: Design Synthesis and Biological Evaluation of 2 Phenyl 1 Benzofuranone Derivatives as Probable Anticancer Agents
Researcher: Raghava D
Guide(s): Mittal Abhilasha, Babu G. Sridhar
Keywords: Clinical Pre Clinical and Health
Pharmacology and Pharmacy, ADMET, Anti Cancer activity, G361 cell line, Sulforhodamine assay
Pharmacology and Toxicology
University: Nims University Rajasthan
Completed Date: 2020
Abstract: Docking studies are the most prominent study in the current trend for analysing macromolecular and nanomolecular interactions. Synthetic routes may to laborious process and long times to complete a stucture but computional techniques are developed such that to build structure and analyse possible biological activities. A group of 324 molecules were developed and screened for virtual screening, ADMET predictions and Docking studies which were compared with marketed products of same category. Benzofuranone is a bicyclic ring where a benzene ring fused with a furanone. Synthetic chemistry plays a major in developing a series of potent anti cancer agents. Benzofuranone was synthesized by reacting benzene diols and triols with bromo phenyl acetonitrile yielded an imine derivative are converted to ketone with treatment with hydrochloric acid then cyclised with sodium acetate. The compounds identity and purity are confirmed by spectral and analytical methods. Benzofuranone derivatives are screened antineoplastic activity was performed against human skin cancer cell line G361 at micro molecular concentrations. The compounds IA, IB, ID,IE,IF, IIB,IIC, IIIA, IVB, IVF, VA, VC, VD, VE was found to be with potent activity. The compounds IA and VC has been shown excellent activity in histopathological studies. newlineKey words: Anti cancer activity, Skin cancer, G361 cell line, Sulforhodamine assay. newline
Pagination: 1-27, 1-371
Appears in Departments:Department of Pharmaceutical Sciences

Files in This Item:
File Description SizeFormat 
01 title page.pdfAttached File250.5 kBAdobe PDFView/Open
02 abstract.pdf175.68 kBAdobe PDFView/Open
03 acknowledgement.pdf176.26 kBAdobe PDFView/Open
04 undertaking.pdf216.59 kBAdobe PDFView/Open
05 certificate of supervisor.pdf250.88 kBAdobe PDFView/Open
06 certificate of co-supervisor.pdf217.81 kBAdobe PDFView/Open
07 contents.pdf197.41 kBAdobe PDFView/Open
08 list of tables.pdf204.22 kBAdobe PDFView/Open
09 list of figures.pdf353.73 kBAdobe PDFView/Open
10 abbreviations.pdf188.46 kBAdobe PDFView/Open
11 list of annexure.pdf8.38 kBAdobe PDFView/Open
12 list of appendices.pdf176.14 kBAdobe PDFView/Open
13 chapter 1.pdf726.37 kBAdobe PDFView/Open
14 chpater 2.pdf1.05 MBAdobe PDFView/Open
15 chapter 3.pdf993.46 kBAdobe PDFView/Open
16 chapter 4.pdf10.14 MBAdobe PDFView/Open
17 chapter 5.pdf751.46 kBAdobe PDFView/Open
18 chapter 6.pdf498.23 kBAdobe PDFView/Open
19 bibliography.pdf655.23 kBAdobe PDFView/Open
20 annexure- list of publications, seminars & coferences and appendices.pdf373.54 kBAdobe PDFView/Open
21 1st publication.pdf4.33 MBAdobe PDFView/Open
22 2nd publication.pdf4.64 MBAdobe PDFView/Open
23 3rd publication.pdf2.06 MBAdobe PDFView/Open
24 4th publication.pdf1.73 MBAdobe PDFView/Open
25 5th publication.pdf3.09 MBAdobe PDFView/Open
26 1st seminar (abstract & certificate).pdf857.52 kBAdobe PDFView/Open
27 1st conference (abstract & certificate).pdf832.79 kBAdobe PDFView/Open
28 2nd conferene (abstract & certificate).pdf898.81 kBAdobe PDFView/Open
29 docking training certificate.pdf618.2 kBAdobe PDFView/Open
30 chemical and lab. utilization.pdf452.37 kBAdobe PDFView/Open
31 anti cancer activity bill.pdf539.63 kBAdobe PDFView/Open
32 expenditure.pdf383.21 kBAdobe PDFView/Open
80_recommendation.pdf744.59 kBAdobe PDFView/Open

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