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Title: Genetic Analysis of Steroid Resistance Nephrotic Syndrome in South Indian Children
Researcher: Arvind Selva Kumar
Guide(s): Prabha Senguttavan
Keywords: Clinical Pre Clinical and Health,Clinical Medicine,Pediatrics child
University: The Tamil Nadu Dr. M.G.R. Medical University
Completed Date: 2014
Abstract: This research work attempts to tell the story of the last seven years study of genetic work on Nephrotic Syndrome (NS) in south Indian children. It does not pretend to be a formal history of the subject nor does it try to undertake detail genetic analysis of NS patients. In India, NS and their genetic stories were mostly untold which made it important and imperative to record them in some permanent and accessible form before it was too late. To our knowledge, this is the first ethnic/geographical based NS study in India. For this study, the need for collaboration between the two very different worlds of experts like basic scientists (medical genetics) and clinicians suddenly become essential. An important factor in this early phase was the involvement of key linking individuals who had both clinical and genetic expertise and who were thus able to play a particularly active role in initiating and focusing the collaboration. Our result output regarding genetic (molecular/cytogenetic/immunogenetic) is due to the joint efforts of basic scientists and clinicians. These collaborations seem to have been fruitful and useful for both, each recognizing and respecting the others skills and role. The molecular mechanisms of proteinuria in kidney diseases that lead to renal failure are poorly understood. This research work has four chapters. Chapters I and II focus on mutation analysis in WT1 and NPHS2 genes, and then III and IV Chapters deal with polymorphism analysis of HLA- class II and ACE of NS and control subjects. newline
Pagination: 218
Appears in Departments:Department of Medical

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01_title.pdf.pdfAttached File76.91 kBAdobe PDFView/Open
02_certificate.pdf.pdf31.1 kBAdobe PDFView/Open
03_declaration.pdf.pdf135.75 kBAdobe PDFView/Open
10_chapter1.pdf1.44 MBAdobe PDFView/Open
11_chapter2.pdf24.08 kBAdobe PDFView/Open
12_chapter3.pdf155.58 kBAdobe PDFView/Open
13_chapter4.pdf1.59 MBAdobe PDFView/Open
14_chapter5.pdf830.79 kBAdobe PDFView/Open
15_chapter6.pdf1.38 MBAdobe PDFView/Open
16_chapter7.pdf641.83 kBAdobe PDFView/Open
17_summary_and_conclusion.pdf.pdf25.82 kBAdobe PDFView/Open
18_recommendations_of_the_study.pdf25.2 kBAdobe PDFView/Open
19_references.pdf.pdf306.58 kBAdobe PDFView/Open
20_appendix.pdf.pdf1.92 MBAdobe PDFView/Open
21_publications.pdf.pdf422.56 kBAdobe PDFView/Open

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