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Title: Drug interaction studies of allopathic drugs with alternative system of medicines
Researcher: Burhan Aslam Usmangani
Guide(s): Vyas Bhavin A
Keywords: Pharmacology
University: Uka Tarsadia University
Completed Date: 2019
Abstract: With the advent of polytherapy, the use of herbal supplements and traditional medicines becomes increasingly popular for its health and therapeutic benefits recently. Looking to this scenario, drug interactions have become common clinical problem and drug interaction occurs when the pharmacokinetic or pharmacodynamic of a drug in the body are altered by the presence of one or more interacting substances. newlineMoreover, herbal medicines fall into category of alternative and complementary medicines. They are not regulated with same scrutiny as that of conventional drugs. These products are available to the consumers as over-the counter (OTC) medicines in different formulations and doses. They are generally taken with conventional drugs with or without consulting the physician. It has been documented that as many as 31% of patients use herbal supplements concurrently with prescribed drugs and 70% of them do not report the use of these products to their physician. These are generally self-administered along with therapeutic drugs. The reasons for such herbal consumption may be due the following facts; a general newlinemisconception that herbal medicines are safe and free from side effects and drug interactions, because these products are of natural origin. Typically, it is considered that the traditional health aid which does not require stringent preclinical and clinical assessments. Such widely held view is unfortunately not true and often misleading. Thus, there is increase in possibility for herb-drug interactions leading to beneficial, toxic or sometime may be fatal clinical outcome of the therapy. The aim and objective of the present work was to determine the drug-herb pharmacokinetic interactions of Tinospora cordifolia in vitro CYP inhibition assay and in vivo pharmacokinetics interaction studies with rifampicin, idazolam and atenolol.
Pagination: All Pages
Appears in Departments:Faculty of Pharmacy

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