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Title: Studies on the effects of plant lectins on hematopoietic stem cells
Researcher: Hinge, Ashwini S
Guide(s): Kale, V P
Keywords: Plant lectins
Hematopoietic stem cells
Cell Sciences
Upload Date: 1-Sep-2011
University: University of Pune
Completed Date: 2009
Abstract: Epidemiological studies have shown that the diets rich in fruits, herbs and spices are associated with good health and low risk of cardiovascular disease and these foods are rich in lectins. After ingestion, most lectins bind to the absorptive microvilli of the small intestine, and from there they may gain access into the circulation through endocytosis, ultimately reaching various tissues. The resistance of the lectins towards the proteolytic activities of digestive enzymes and their ability to enter systemic circulation and tissues, taken together with their ability to bind to cell surface molecules containing specific carbohydrate moieties, indicate that they may affect the functions of various tissues. Accordingly, it is of considerable importance to establish whether a given lectin has deleterious or beneficial effects for mammals. In the present study, we have made a systematic attempt to examine the effects of two mannose-specific plant lectins namely, banana lectin (BL) and garlic lectin (GL), on the hematopoietic stem/progenitor cells. Since both BL and GL are the constituents of commonly consumed food items – banana and Garlic – it was imperative to study the effect of an oral administration of these lectins on the hematopoiesis of mice. The mice were fed with the lectins on weekly basis for various time periods and their marrow cells were subjected to stem cell-specific functional and phenotypic assays. The output of these various assays clearly indicated that an oral administration of both BL and GL leads to an increase in the hematopoietic stem/progenitor (HSPC) pool of the mice.
Pagination: 197p.
Appears in Departments:National Centre for Cell Science

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02_certificate.pdf37.74 kBAdobe PDFView/Open
03_declaration.pdf36.19 kBAdobe PDFView/Open
04_acknowledgment.pdf39.56 kBAdobe PDFView/Open
05_table of contents.pdf37.84 kBAdobe PDFView/Open
06_abbreviations.pdf109.46 kBAdobe PDFView/Open
07_abstract.pdf81.45 kBAdobe PDFView/Open
08_introduction.pdf131.57 kBAdobe PDFView/Open
09_chapter 1.pdf937.59 kBAdobe PDFView/Open
10_chapter 2.pdf242.56 kBAdobe PDFView/Open
11_chapter 3.pdf1.92 MBAdobe PDFView/Open
12_chapter 4.pdf187.15 kBAdobe PDFView/Open
13_chapter 5.pdf118.87 kBAdobe PDFView/Open
14_references.pdf208.25 kBAdobe PDFView/Open
15_appendices.pdf183.78 kBAdobe PDFView/Open

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