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Title: Studies on gelatin based antioxidant enriched biomaterials
Researcher: Selestin raja I
Guide(s): Nishad fathima N
Keywords: biomaterials
Life Sciences,Biology and Biochemistry,Biochemistry and Molecular Biology
University: Anna University
Completed Date: 2018
Abstract: Nowadays, researchers are keen on developing antioxidant newlinebiomaterials for relieving oxidative stress, which causes variety of ailments in newlinehuman body. Gelatin has been explored well as drug delivery carrier to deal newlinewith oxidative stress in the forms of capsule, hydrogel and wound dressing newlinematerial. Though many literatures are available to study about gelatin based newlinehydrogel systems, drug release from wet hydrogel has not been systematically newlineexplained. Further, other drug delivery forms such as micelle and newlineencapsulating agent based on gelatin have not been explained thoroughly, due newlineto its soluble and hydrophilic nature in water.To address the above mentioned issues, non-conventional characterizations viz. Thermoporometry and Alternative Current Impedance newlineAnalysis have been employed to study dynamics of water and dielectric newlineresponse of polymeric components of hydrogel, respectively. Gelatinchitosan, newlinegelatin-PVA and gelatin-glutathione were the hydrogel composites newlineinvestigated for the purpose. Genipin and carbodiimide were used as cross newlinelinking agents. Generally, pore size, cross linkage and nature of polymeric newlinecomponents are the main factors to control drug release from a hydrogel newlinematrix. Evaluation of thermodynamics of free and bound water content has newlineprovided elucidative details of pore size distribution in wet hydrogel whereas newlinedielectric properties of polymeric components yield to study cross linking newlinedensity and hydrophilicity. In addition, characterizations such as FTIR, SEM newlineand colorimetric assays were supporting the results of non-conventional newlinecharacterizations carried out. newline newline
Pagination: xxxii, 134p.
Appears in Departments:Faculty of Science and Humanities

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01_title.pdfAttached File9.93 kBAdobe PDFView/Open
02_certificates.pdf151.23 kBAdobe PDFView/Open
03_abstract.pdf9.79 kBAdobe PDFView/Open
04_acknowledgment.pdf81.76 kBAdobe PDFView/Open
05_contents.pdf312.91 kBAdobe PDFView/Open
06_chapter1.pdf320.84 kBAdobe PDFView/Open
07_chapter2.pdf919.65 kBAdobe PDFView/Open
08_chapter3.pdf569.27 kBAdobe PDFView/Open
09_chapter4.pdf674.11 kBAdobe PDFView/Open
10_chapter5.pdf522.64 kBAdobe PDFView/Open
11_conclusion.pdf116.47 kBAdobe PDFView/Open
12_references.pdf172.23 kBAdobe PDFView/Open
13_publications.pdf96.83 kBAdobe PDFView/Open

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