Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/253273
Title: Certain investigations on the performance of hemodialyser membrane based on morphological characteristics and modeling and simulation techniques
Researcher: Sangeetha M S
Guide(s): Kandaswamy A
Keywords: hemodialyser
Physical Sciences,Space Sciences,Astronomy and Astrophysics space science
Simulation techniques
University: Anna University
Completed Date: 2018
Abstract: Hemodialysis is the most widely used Renal Replacement Therapy newlinefor the treatment of failed kidneys. In the event of kidney failure, the newlineunwanted substances that accumulate in the blood needs to be excreted. newlineIncreased acid levels and abnormal levels of Urea, Creatinine, Glucose, newlineEndothelin, and#1049109;2-Microglobulin and Complement Factor D indicate the newlinemalfunctioning of the kidneys. Serum urea and creatinine are the two main newlinebiomarkers that assess the performance of the human kidneys. The newlinehemodialyser known as the Artificial kidney is the replacement of the newlinenatural kidney and is the heart of the hemodialyser machine. The dialyser newlinemodule comprises of thousands of hollow fibers which act as the newlinesemipermeable membrane to filter the impurities from the blood. The newlineperformance of the dialyser is dictated by the membrane design and chemical newlinecomposition. One of the main challenges in hemodialyser membrane design is newlineto enhance the clearance rate of solutes. The main objective of this thesis is to newlineinvestigate the factors affecting the performance of the hemodialyser and to newlineenhance its filtering efficiency. Morphological studies were performed to newlineunderstand the structural details of the hollow fiber membrane, as the newlinestructure decides the performance of the membrane. Computer aided newlinemodeling and simulation techniques help to analyse the critical parameters newlinethat affect the dialysis process and identify the means to enhance the filtering newlineefficiency. newline newline
Pagination: xxii, 151p.
URI: http://hdl.handle.net/10603/253273
Appears in Departments:Faculty of Technology

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01_title.pdfAttached File134.67 kBAdobe PDFView/Open
02_certificates.pdf94.34 kBAdobe PDFView/Open
03_abstract.pdf120.33 kBAdobe PDFView/Open
04_acknowledgment.pdf94.96 kBAdobe PDFView/Open
05_contents.pdf122.82 kBAdobe PDFView/Open
06_chapter1.pdf1 MBAdobe PDFView/Open
07_chapter2.pdf2.92 MBAdobe PDFView/Open
08_chapter3.pdf1.18 MBAdobe PDFView/Open
09_chapter4.pdf11.21 MBAdobe PDFView/Open
10_chapter5.pdf1.69 MBAdobe PDFView/Open
11_chapter6.pdf1.12 MBAdobe PDFView/Open
12_conclusion.pdf141.12 kBAdobe PDFView/Open
13_references.pdf200.45 kBAdobe PDFView/Open
14_publications.pdf148.66 kBAdobe PDFView/Open


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