Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/249629
Title: A study on the possible role of mitochondrial damage reactive nitrogen species and reactive oxygen species in the pathogenesis of methotrexate induced small intestinal damage in the rat
Researcher: Viswa Kalyan Kolli
Guide(s): Premila Abraham
Keywords: Life Sciences,Biology and Biochemistry,Biochemical Research Methods
University: The Tamil Nadu Dr. M.G.R. Medical University
Completed Date: 2011
Abstract: Methotrexate (MTX) (4-amino-N10-methylpteroyl glutamic acid) is an analogue of folic acid. It is used as antifolate and antimetabolite in the treatment of various malignancies. It was developed by Y. Subba Rao, a professor of biochemistry at Harvard Medical School. He had originally developed folic acid and later developed several folic acid analogues. Inspired by the observations in mid 1940s about the role of folic acid in the inhibition of sarcomas, Sydney Farber a pathologist at the Boston Children s Hospital had worked on folic acid antagonists in wide variety of malignancies. Among the folic acid analogues, aminopterin was the first drug used to treat children suffering with acute lymphoblastic leukemia (ALL). But, the use of this drug is limited by its side effects seen chiefly in the mouth and in the intestinal tract where hemorrhages occurred frequently. Later, another less toxic antifolate called methotrexate (amethopterin), developed by Y. Subba Rao was tried and found to be safer and more effective. Since then, MTX is the most preferred drug of choice in the treatment of malignancies. Methotrexate is a widely used drug in the treatment of various carcinomas, lymphomas and sarcomas. It is also used in the treatment of rheumatoid arthritis, psoriasis, ectopic pregnancy and inflammatory bowel disease. Melatonin has been administered in both physiological and pharmacological amounts to humans and animals, and there is widespread agreement that it is a non-toxic molecule. Beneficial antioxidant effects of melatonin have been recently shown in clinical settings for several chronic diseases, including patients with rheumatoid arthritis, elderly patients with primary essential hypertension, and females with infertility. It is therefore concluded that melatonin appeared to hold promise as an agent that can potentially reduce MTX induced small intestinal damage. newline newline newline
Pagination: 247
URI: http://hdl.handle.net/10603/249629
Appears in Departments:Department of Medical

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06_chapter1.pdf60.09 kBAdobe PDFView/Open
07_chapter2.pdf43.64 kBAdobe PDFView/Open
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11_chapter6.pdf4.93 MBAdobe PDFView/Open
12_chapter7.pdf47.65 kBAdobe PDFView/Open
13_chapter8.pdf43.91 kBAdobe PDFView/Open
14_bibliography.pdf233.73 kBAdobe PDFView/Open
15_publications.pdf45.16 kBAdobe PDFView/Open


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