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Title: Design and In Vitro Evaluation Of Muco Adhesive Tablet of Posaconazole
Researcher: Mohiuddin Mohd Hamed
Guide(s): Sharma Shailesh
Keywords: Clinical Pre Clinical and Health,Pharmacology and Toxicology,Pharmacology and Pharmacy, Posaconaole; and#946;- Cyclodextrin; HPMC; Carbopol; Mucoadhesive
University: Nims University Rajasthan
Completed Date: 2019
Abstract: An attempt was made to design and develop mucoadhesive tablet formulation of posaconazole against candida albicans in immunocompromised pateints. Poorly soluble drugs are very challenging to formulate in oral mucoadhesive dosage form. Whereas lipophilic drugs, well absorbed through oral mucosa, but shows very low fluxes hence exhibit difficulty in transport across mucosa. The complexation of posaconazole with and#946;- cyclodextrin was studied by phase solubility method which indicates the formation of complex with 1:1 stoichiometry. The muccoadhesive tablets for the delivery of posaconazole were prepared by compression using carbopol and HPMC. The assessment of buccal administration of posaconazole was analyzed by penetration through in-vitro excised goat mucosa. The results of experimented study reveals that, as there was increase in drug release rate from the tablets in solution as well as an increase in the amount of posaconazole permeated through sheep buccal mucosa. An attempt was made to study the suitability of posacanazole in buccal drug delivery system1. newlineKEYWORDS: Posaconaole; and#946;- Cyclodextrin; HPMC; Carbopol; Mucoadhesive. newline
Pagination: 1-13, 1-115
Appears in Departments:Department of Pharmaceutical Sciences

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