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Title: A study on the role of osteopontin in regulation of vascular endothelial growth factor vegf expression angiogenesis and tumor growth
Researcher: Chakraborty, Goutam
Guide(s): Kundu, Gopal C
Keywords: Biotechnology
Upload Date: 25-Aug-2011
University: University of Pune
Completed Date: 2008
Abstract: Cancer or the malignancies of the cells has been considered as one of the most dreadly disease. The majority of the death caused by cancer is due to the distant migration of the cancer cells and the phenomenon is termed as tumor metastasis. Angiogenesis or neovascurarization or formation of the new blood vessels from the existing one plays crucial role during tumor progression. Recent studies from various laboratories indicated that angiogenesis not only provide nutrients to the tumor cells but also help the tumor cells to metastasize to the distant parts of the body. Thus, angiogenesis is considered as the most important step not only for the tumor growth but also for the tumor metastasis and therefore, understanding the molecular mechanism underlying the regulation of angiogenesis may help to invent novel approaches for cancer therapy. Osteopontin (OPN), the ECM associated calcified phosphosialoprotein has been considered as one of the major molecule which play crucial role in tumor metastasis. In this study using multiple in vitro and in vivo approaches we have demonstrated for the first time that OPN acts as an important angiogenic factor that augments the expression of vascular endothelial growth factor (VEGF) and regulates tumor angiogenesis in breast cancer model.
Pagination: 118p.
Appears in Departments:Department of Biotechnology

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01_title.pdf77.14 kBAdobe PDFView/Open
02_certificate.pdf34.46 kBAdobe PDFView/Open
03_declaration.pdf40.57 kBAdobe PDFView/Open
04_acknowledgement.pdf51.41 kBAdobe PDFView/Open
05_index.pdf46.74 kBAdobe PDFView/Open
06_abbriviations.pdf88.66 kBAdobe PDFView/Open
07_abstract.pdf63.06 kBAdobe PDFView/Open
08_introduction.pdf1.69 MBAdobe PDFView/Open
09_aims & objective.pdf470.54 kBAdobe PDFView/Open
10_materials & methods.pdf614.13 kBAdobe PDFView/Open
11_results & discussion.pdf2.67 MBAdobe PDFView/Open
12_summary & conclusion.pdf533.18 kBAdobe PDFView/Open
13_bibliography.pdf517.02 kBAdobe PDFView/Open
14_appendix.pdf425.69 kBAdobe PDFView/Open
15_research article.pdf4.27 MBAdobe PDFView/Open

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