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Title: Biochemical and molecular studies on sporulation in bacillus anthracis
Researcher: Mattoo, Abid R
Guide(s): Singh, Yogendra
Keywords: Biotechnology
Upload Date: 25-Aug-2011
University: University of Pune
Completed Date: 26/09/2005
Abstract: The etiological agent of anthrax, Bacillus anthracis, is a uniquely pervasive and persistent environmental pathogen due to its ability to form dormant spores that are resistant to adverse environmental conditions such as extremes of temperature, UV radiation, and antimicrobial chemical agents. The spore is essential to the organism not only for its persistence in the environment but also for the ability of this organism to infect its hosts. Infection is initiated when spores are introduced into the host body and phagocytosed by macrophage and other phagocytic cells. It is believed that this is followed by germination of the spores into vegetative cells, with subsequent toxin gene expression and capsule production, resulting in the onset of anthrax disease. The molecular mechanism of sporulation in B. anthracis is poorly understood. The initiation of sporulation in a closely related Bacillus subtilis is controlled by the phosphorelay signal transduction system. After the genome sequence of B. anthracis was out in 2003, it was observed that the B. anthracis chromosome encodes machinery for sporulation that is broadly similar to B. subtilis. The phosphorelay of B.subtilis is activated by five histidine sensor kinases (KinA, KinB, KinC, KinD and Kin E) in response to stress signals. The target of their activation is the Spo0F response regulator (RR), to which they transfer a phosphoryl group.
Pagination: 142p.
Appears in Departments:Department of Biotechnology

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01_title.pdfAttached File103.13 kBAdobe PDFView/Open
02_declaration.pdf65.98 kBAdobe PDFView/Open
03_acknowledgements.pdf78.65 kBAdobe PDFView/Open
04_contents.pdf46.12 kBAdobe PDFView/Open
05_abstract.pdf68.39 kBAdobe PDFView/Open
06_table of contents.pdf90.99 kBAdobe PDFView/Open
07_list of figures.pdf98.97 kBAdobe PDFView/Open
08_abbriviations.pdf93.3 kBAdobe PDFView/Open
09_review of literature.pdf434.61 kBAdobe PDFView/Open
10_materials and methods.pdf205.24 kBAdobe PDFView/Open
11_chapter1.pdf1.69 MBAdobe PDFView/Open
12_chapter2.pdf2.14 MBAdobe PDFView/Open
13_publications.pdf97.67 kBAdobe PDFView/Open
14_summary and conclusion.pdf69.71 kBAdobe PDFView/Open
15_bibliography.pdf201.51 kBAdobe PDFView/Open
16_appendices.pdf89.66 kBAdobe PDFView/Open

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