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Title: Modeling and control of fed batch fermentation process for the production of recombinant protein in escherichia coli
Researcher: Geethalakshmi, S
Guide(s): Pappa, N
Keywords: electrical engineering
fermentation process
Upload Date: 19-Aug-2014
University: Anna University
Completed Date: 01/04/2012
Abstract: Rapid development of novel recombinant proteins based on newlinegenetically engineered Escherichia coli using fed batch fermentation newlinetechniques is imperative for cost effective production of such products at newlineindustrial scale Mechanistic understanding of the fermentation process for newlinerecombinant protein through model based monitoring and control of key newlineprocess variables is vital to accomplish such objectives Lack of online sensors for the measurement of process variables and intracellular metabolites hinder the development of accurate model to describe fermentation process A simple unstructured model developed with newlinelimited state variables and constant process parameters has limitations in newlinepredicting the response of the complex and nonlinear recombinant protein newlineproduction process for wide operating conditions and therefore not suitable as newlinea generic model In this work a segregated, unstructured model has been formulated newlineto describe coli based fermentation processes for various recombinant newlineproteins The predictive capability of unstructured model for different newlineoperating conditions and genetic insert was found to be limited due to wide newlinedisparity in process parameters newline newline
Pagination: vi,98P.
Appears in Departments:Faculty of Electrical and Electronics Engineering

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01_title.pdfAttached File178.25 kBAdobe PDFView/Open
02_certificates.pdf2.12 MBAdobe PDFView/Open
03_abstract.pdf62.1 kBAdobe PDFView/Open
04_acknowledgement.pdf58.7 kBAdobe PDFView/Open
05_contents.pdf154.32 kBAdobe PDFView/Open
06_chapter 1.pdf186.2 kBAdobe PDFView/Open
07_chapter 2.pdf198.89 kBAdobe PDFView/Open
08_chapter 3.pdf1.32 MBAdobe PDFView/Open
09_chapter 4.pdf244.8 kBAdobe PDFView/Open
10_chapter 5.pdf76.12 kBAdobe PDFView/Open
11_references.pdf184.6 kBAdobe PDFView/Open
12_publications.pdf71.93 kBAdobe PDFView/Open
13_vitae.pdf49.28 kBAdobe PDFView/Open

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