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dc.description.abstractThe thesis entitled Identifying novel chemotypes against breast cancer: Design, synthesis and newlinebiological evaluation was initiated on January 2014 under the supervision of Dr. Subhabrata newlineSen (supervisor) and Dr. Shailja Singh (co-supervisor), The primary objective of this present work newlineis to access the novel chemotypes against breast cancer through diverse synthetic strategies. The newlinethesis comprises of five chapters. In Chapter 1 we have provided a concise review on breast cancer, newlineconcerned molecular targets and various therapeutic approaches to treat breast cancer. In Chapter newline2 we described a modular synthetic strategy of natural product inspired hybrid scaffolds. In newlineChapter 3 we described a facile three component synthesis of 5-arylidene-2-aminothiazolidinones. newlineIn Chapter 4 we reported design and synthesis of polysubstituted olefin library via intuitive newlinescaffold hopping and bioisosteric modification of known breast cancer molecules Tamoxifen. In newlineChapter 5 we have demonstrated a facile synthesis of a library of novel hybrid compounds through newlineintramolecular oxidative ring contraction of appropriate carbolines. newline
dc.format.extentXVIII, 258p.
dc.titleIndentifying novel chemotypes against breast cancer design synthesis and biological evalution
dc.creator.researcherBathula Chandramohan
dc.contributor.guideSubhabrata Sen
dc.publisher.placeGreater Noida
dc.publisher.universityShiv Nadar University
dc.publisher.institutionDepartment of Chemistry
Appears in Departments:Department of Chemistry

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bibilography.docxAttached File39.55 kBMicrosoft Word XMLView/Open
certificates.pdf88.22 kBAdobe PDFView/Open
chapter 1.docx204.35 kBMicrosoft Word XMLView/Open
chapter 2.docx1.35 MBMicrosoft Word XMLView/Open
chapter 3.docx631.49 kBMicrosoft Word XMLView/Open
chapter 4 .docx4.39 MBMicrosoft Word XMLView/Open
chapter 5.docx295.47 kBMicrosoft Word XMLView/Open
conclusion an future prospective.docx16.79 kBMicrosoft Word XMLView/Open
preliminary pages.pdf186.32 kBAdobe PDFView/Open
title page.pdf62.55 kBAdobe PDFView/Open

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