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Title: Indentifying novel chemotypes against breast cancer design synthesis and biological evalution
Researcher: Bathula Chandramohan
Guide(s): Subhabrata Sen
Keywords: Chemistry
University: Shiv Nadar University
Completed Date: 2017
Abstract: The thesis entitled Identifying novel chemotypes against breast cancer: Design, synthesis and newlinebiological evaluation was initiated on January 2014 under the supervision of Dr. Subhabrata newlineSen (supervisor) and Dr. Shailja Singh (co-supervisor), The primary objective of this present work newlineis to access the novel chemotypes against breast cancer through diverse synthetic strategies. The newlinethesis comprises of five chapters. In Chapter 1 we have provided a concise review on breast cancer, newlineconcerned molecular targets and various therapeutic approaches to treat breast cancer. In Chapter newline2 we described a modular synthetic strategy of natural product inspired hybrid scaffolds. In newlineChapter 3 we described a facile three component synthesis of 5-arylidene-2-aminothiazolidinones. newlineIn Chapter 4 we reported design and synthesis of polysubstituted olefin library via intuitive newlinescaffold hopping and bioisosteric modification of known breast cancer molecules Tamoxifen. In newlineChapter 5 we have demonstrated a facile synthesis of a library of novel hybrid compounds through newlineintramolecular oxidative ring contraction of appropriate carbolines. newline
Pagination: XVIII, 258p.
Appears in Departments:Department of Chemistry

Files in This Item:
File Description SizeFormat 
bibilography.docxAttached File39.55 kBMicrosoft Word XMLView/Open
certificates.pdf88.22 kBAdobe PDFView/Open
chapter 1.docx204.35 kBMicrosoft Word XMLView/Open
chapter 2.docx1.35 MBMicrosoft Word XMLView/Open
chapter 3.docx631.49 kBMicrosoft Word XMLView/Open
chapter 4 .docx4.39 MBMicrosoft Word XMLView/Open
chapter 5.docx295.47 kBMicrosoft Word XMLView/Open
conclusion an future prospective.docx16.79 kBMicrosoft Word XMLView/Open
preliminary pages.pdf186.32 kBAdobe PDFView/Open
title page.pdf62.55 kBAdobe PDFView/Open

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