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Title: Studies on the haematological, biochemical, immunological, histopathological, and molecular aspects of the human breast carcinoma
Researcher: Christina, A Sheeba
Guide(s): Daniel, G Swamidoss
Keywords: haematological
Upload Date: 8-Jun-2011
University: Prist University
Completed Date: December, 2010
Abstract: The present research study deals with the Human Breast Carcinoma which is prevalent in women of all ages and one of the causes of cancer related deaths. The study group comprising of 100 women which was divided into four groups namely, control subjects, Non-metastatic group (stage 0, I and II), Metastatic group (stage III, IV and V) and Post-treatment group. The Research work was carried out at the Department of Biotechnology, PRIST University Thanjavur, India (Lat. 100 N’., Long. 790 E’.) and in Molecular Biology laboratories. Standard procedures and protocols were followed for analyses of 37 parameters belonging to the Haematological, Biochemical,Immunological, Histopathological and Molecular aspects. In the Haematology, a decreasing trend of blood cells except platelets was recorded in all the 3 groups. In the Biochemical analyses a uniform elevation of Oxidative stress, Antioxidants, Tumour Markers and Estradiol was recorded, which serves as predictive factors of Breast cancer. In Immunological studies elevated trend was noted in IgG and IgA, Inflammatory markers and Cytokines, while a decrease in Antiinflammatory marker was recorded which also serves as indicators of breast cancer. In Histopathological studies (biopsy), Ductal carcinoma was found to be more prevalent han Lobular carcinoma in all the three women groups. The Molecular studies revealed that DNA damage was found progressively more from group I to group IV and also more in >50 age group and also in Post-menopausal women. Elevated expression of receptors namely, Her2/neu, Estrogen receptors and Progesterone receptors were recorded as signs of progression of breast carcinoma.
Pagination: xvii, 171p.
Appears in Departments:Department Of Biotechnology

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02_certificate.pdf20.97 kBAdobe PDFView/Open
03_declaration.pdf17.53 kBAdobe PDFView/Open
04_abstract.pdf18.66 kBAdobe PDFView/Open
05_acknowledgement.pdf35.29 kBAdobe PDFView/Open
06_content.pdf32.22 kBAdobe PDFView/Open
07_list of tables.pdf22.6 kBAdobe PDFView/Open
08_list of plates.pdf13.82 kBAdobe PDFView/Open
09_list of figures.pdf22.7 kBAdobe PDFView/Open
10_list of abbreviation.pdf21.63 kBAdobe PDFView/Open
11_chapter 1.pdf186.65 kBAdobe PDFView/Open
12_chapter 2.pdf235.13 kBAdobe PDFView/Open
13_chapter 3.pdf308.34 kBAdobe PDFView/Open
14_chapter 4.pdf130.33 kBAdobe PDFView/Open
15_chapter3- histograms.pdf438.7 kBAdobe PDFView/Open
16_chapter 3- histogramsold.pdf353.72 kBAdobe PDFView/Open
17_chapter 3- tables.pdf63.61 kBAdobe PDFView/Open
18_chapter 5.pdf402.21 kBAdobe PDFView/Open
19_appendix.pdf17.84 kBAdobe PDFView/Open
20_figure.pdf8.53 kBAdobe PDFView/Open
21_figure.pdf5.87 MBAdobe PDFView/Open
22_figure.pdf19 MBAdobe PDFView/Open

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