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Title: Genomic and proteomic studies in systematic Lupus Erythematosus pateints with distinct autoantibody specificities to nuclear autoantigens
Researcher: Rai, Richa
Guide(s): Rai, Geeta
Keywords: Lupus Erythematosus Pateints --Genomic Study
Lupus Erythematosus Pateints --Proteomic Study
University: Banaras Hindu University
Completed Date: 2015
Abstract: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease with enormous heterogeneity in clinical manifestations and autoantibody repertoires. The classical manifestations of SLE include nephritis, pericarditis, arthritis, rashes, etc., and are supposed to result from exuberant autoantibody responses against nuclear and cytoplasmic components. Two major groups of autoantibodies present in SLE patients are predominantly directed against nuclear antigens specifically double stranded DNA (dsDNA) and extractable nuclear antigens (ENA) though, the mechanisms underlying this distinct autoantibody profile is poorly understood (Sherer et al., 2004; To et al., 2005). The etiology of SLE is multifactorial involving genetic, environmental and epigenetic factors (Hocheberg et al., 1997; Danchenko et al., 2006). However, there is no general unifying theory which could explain the basis of heterogeneity in autoantibody repertoire.
Appears in Departments:Department of Molecular & Human Genetics

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chapter 2.pdf1.26 MBAdobe PDFView/Open
chapter 3.pdf5.49 MBAdobe PDFView/Open
chapter 4.pdf1.41 MBAdobe PDFView/Open
chapter 5.pdf2.44 MBAdobe PDFView/Open
chapter 6.pdf846.22 kBAdobe PDFView/Open
chapter 7.pdf475.45 kBAdobe PDFView/Open
preliminary pages.pdf1.34 MBAdobe PDFView/Open
references.pdf692.79 kBAdobe PDFView/Open
title.pdf462.11 kBAdobe PDFView/Open

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