Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/204239
Title: Human Immunodeficiency Virus type 1 reverse transcriptase and protease gene mutations
Researcher: Abraham Joseph Kandathil
Guide(s): Sridharan G
Keywords: antiretroviral interactions
Human Immunodeficiency Virus type 1
protease gene mutations
reverse transcriptase
University: The Tamil Nadu Dr. M.G.R. Medical University
Completed Date: 2008
Abstract: Human immunodeficiency virus (HIV) belongs to the family Retroviridae and the subfamily lentivirinae. The other medically important members in this family include human Tlymphotropic viruses I and II. The HIV is of two types and are designated HIV-1 and HIV-2. HIV-1 and 2 are subdivided based on genetic differences and are divided into groups and clades/subtypes. This combination of drugs is called antiretroviral therapy (ART) has been found to be effective in controlling HIV infections than administration of only one drug. The findings are important with the introduction of a CCR5 antagonist for the treatment of HIV-1 infections. Hence, in such scenarios it would be imperative to determine the co-receptor utilized by the strains before administration of these classes of drugs. Strains resistant to maraviroc have been detected in patients elsewhere in whom they have been administrated. These resistant strains were CXCR4 strains which had emerged from a preexisting population in the patient. It would be important to monitor the scenario when this group of drugs is introduced in India. newline newline newline
Pagination: 256
URI: http://hdl.handle.net/10603/204239
Appears in Departments:Department of Medical

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04_chapter1.pdf126.88 kBAdobe PDFView/Open
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11_chapter8.pdf132.89 kBAdobe PDFView/Open
12_chapter9.pdf110.43 kBAdobe PDFView/Open
13_bibliography.pdf357.37 kBAdobe PDFView/Open
14_appendices.pdf6.02 MBAdobe PDFView/Open


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