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Title: Molecular characterization of indigenous measles virus clades in Tamilnadu
Researcher: Raja D
Guide(s): Nalini Ramamurty
Keywords: Measles
Molecular characterization
transmission pathways
University: The Tamil Nadu Dr. M.G.R. Medical University
Completed Date: 2009
Abstract: Measles is an acute, highly contagious, respiratory viral infection caused by measles virus that belongs to Morbilli genus of the family Paramyxoviridae. Measles is uniquely a human disease, although primates can contract it. However, neither primates nor any other animal reservoir has been identified as capable of maintaining the disease or permitting its spread or reintroduction into human population. Measles is an airborne virus spread by direct contact with droplet from respiratory secretions of infected persons. Patients with measles are most infectious during the late prodromal phase of the illness, when cough and coryza are at their peak. However, the disease is probably contagious from several days before until several days after the onset of rash. In Tamil Nadu state, though high level of immunization coverage is being maintained for the past several years, suspected measles outbreaks are reported from almost all the districts. However laboratory confirmation was very limited. It is observed from the study that for confirmation of measles and rubella by serology timing of sample collection is critical. In the present study, the blood samples were collected between 0 and 41 days after the onset of rash. Approximately 80% of those samples collected within 3 days after the onset of rash were positive. A higher percentage of positivity 86.5% was observed from the samples that were collected between 4 and 10 days after the onset of rash and it decreased to 73.3% if collected between 21 41 days. Virus was isolated from 49 specimens representing 29 outbreaks. Though virus isolation was not useful for case confirmation, this is useful for molecular epidemiological studies. In Tamil Nadu, measles outbreaks were reported from almost all the districts of the state, despite the maintenance of high level immunization coverage in the last decade.
Pagination: 197
Appears in Departments:Department of Medical

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02_preliminary pages.pdf36.26 kBAdobe PDFView/Open
03_chapter1.pdf312.29 kBAdobe PDFView/Open
04_chapter2.pdf363.66 kBAdobe PDFView/Open
05_chapter3.pdf118.32 kBAdobe PDFView/Open
06_chapter4.pdf424.03 kBAdobe PDFView/Open
07_chapter5.pdf366.77 kBAdobe PDFView/Open
08_chapter6.pdf177.2 kBAdobe PDFView/Open
09_chapter7.pdf133.17 kBAdobe PDFView/Open
10_chapter8.pdf113.61 kBAdobe PDFView/Open

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